{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T03:42:06Z","timestamp":1700624526474},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2013,7]]},"abstract":"Objectives<\/jats:title>Antiretroviral (ARV<\/jats:styled-content>) therapy has prolonged the life expectancy of HIV<\/jats:styled-content>\u2010infected persons, increasing their risk of age\u2010associated diseases, including atherosclerosis (AS<\/jats:styled-content>). Decreased risk of AS<\/jats:styled-content> has been associated with the prevention and control of hypertension (HTN<\/jats:styled-content>). We conducted a cohort study of perimenopausal women and older men with or at risk of HIV<\/jats:styled-content> infection to identify risk factors for incident HTN<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Standardized interviews, physical examinations, and laboratory examinations were scheduled at 6\u2010month intervals. Interview data included demographics, medical, family, sexual behaviour and drug use histories, and physical activity.<\/jats:p><\/jats:sec>Results<\/jats:title>There were 330 women and 329 men eligible for inclusion in the study; 27% and 35% of participants developed HTN<\/jats:styled-content> during a median follow\u2010up period of 1080 and 1071 days, respectively. In gender\u2010stratified analysis, adjusting for traditional HTN<\/jats:styled-content> risk factors (age, race, body mass index, smoking, diabetes, family history of HTN<\/jats:styled-content>, alcohol dependence, physical activity and high cholesterol), HIV<\/jats:styled-content> infection was not associated with incident HTN<\/jats:styled-content> in women [hazard ratio (HR<\/jats:styled-content>) 1.31; 95% confidence interval (CI<\/jats:styled-content>) 0.56, 3.06] or men (HR<\/jats:styled-content> 1.67; 95% CI<\/jats:styled-content> 0.75, 3.74). Among HIV<\/jats:styled-content>\u2010infected women, although exposure to ARVs<\/jats:styled-content> was not significantly associated with incident HTN<\/jats:styled-content> (HR<\/jats:styled-content> 0.72; 95% CI<\/jats:styled-content> 0.26, 1.99), CD<\/jats:styled-content>4 T<\/jats:styled-content>\u2010cell count was positively associated with incident HTN<\/jats:styled-content> (HR<\/jats:styled-content> 1.15 per 100 cells\/\u03bcL<\/jats:styled-content>; 95% CI<\/jats:styled-content> 1.03, 1.28). Among physically active HIV<\/jats:styled-content>\u2010infected men, exposure to ARVs<\/jats:styled-content> was negatively associated with incident HTN<\/jats:styled-content> (HR<\/jats:styled-content> 0.15; 95% CI<\/jats:styled-content> 0.03, 0.78).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>HIV<\/jats:styled-content> infection was not associated with incident HTN<\/jats:styled-content> in older men or women. This study provides additional evidence supporting a causal relationship between immune function and incident HTN<\/jats:styled-content>, which warrants further study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12010","type":"journal-article","created":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T14:21:37Z","timestamp":1357568497000},"page":"337-346","source":"Crossref","is-referenced-by-count":3,"title":["Incident hypertension in older women and men with or at risk for HIV<\/scp> infection"],"prefix":"10.1111","volume":"14","author":[{"given":"SH","family":"Factor","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Mount Sinai School of Medicine New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Lo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Mount Sinai School of Medicine New York NY USA"},{"name":"Department of Epidemiology & Population Health Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Schoenbaum","sequence":"additional","affiliation":[{"name":"Department of Epidemiology & Population Health Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RS","family":"Klein","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Mount Sinai School of Medicine New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,7]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"UNAIDS.UNAIDS Outlook report 2010. 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