{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:29:43Z","timestamp":1790206183309,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T00:00:00Z","timestamp":1357689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2013,7]]},"abstract":"Objectives<\/jats:title>Lipoatrophy is a long\u2010term adverse effect of some antiretrovirals that affects quality of life, compromises adherence and may limit the clinical impact of HIV<\/jats:styled-content> treatments. This paper explores the effect of tenofovir\/emtricitabine (TDF<\/jats:styled-content>\/FTC<\/jats:styled-content>) on the amount of limb fat in patients with virological suppression.<\/jats:p><\/jats:sec>Methods<\/jats:title>A randomized, prospective clinical trial was performed to compare continuation on a zidovudine\/lamivudine (ZDV\/3TC<\/jats:styled-content>)\u2010based regimen with switching to a TDF<\/jats:styled-content>\/FTC<\/jats:styled-content>\u2010based regimen in terms of the effect on limb fat mass as assessed by DEXA<\/jats:styled-content> over a 72\u2010week period.<\/jats:p><\/jats:sec>Results<\/jats:title>Eighty patients were included (39 in the TDF<\/jats:styled-content>\/FTC<\/jats:styled-content> arm and 41 in the ZDV<\/jats:styled-content>\/3TC<\/jats:styled-content> arm) and 73 completed the study (37 and 36, respectively). In the switch arm, limb fat increased by a median of 540\u2009g from baseline (P<\/jats:italic>\u2009=\u20090.022), while in the ZDV\/3TC<\/jats:styled-content> arm it decreased by a median of 379\u2009g (P<\/jats:italic>\u2009=\u20090.112; p between groups\u2009=\u20090.007). Subjects with baseline limb fat \u2264\u20097200\u2009g, previous time on ZDV<\/jats:styled-content>\u2009>\u20095 years or a body mass index >\u200925\u2009kg\/m2<\/jats:sup> experienced higher limb fat gains than other subjects, and these differences were statistically significant. Haemoglobin increased by a median of 1.0\u2009g\/dL<\/jats:styled-content> in the TDF<\/jats:styled-content>\/FTC<\/jats:styled-content> arm (P<\/jats:italic>\u2009<\u20090.001) and remained unchanged in the ZDV\/3TC<\/jats:styled-content> arm (p between groups\u2009=\u20090.0002). There were no significant differences between groups in other secondary endpoints (body weight, total body and trunk fat content, total body bone mineral density, laboratory parameters, CD<\/jats:styled-content>4 cell count and viral load).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Switching from a ZDV\/3TC<\/jats:styled-content>\u2010based to a TDF<\/jats:styled-content>\/FTC<\/jats:styled-content>\u2010based regimen led to a statistically significant improvement in limb fat, in contrast to the progressive loss of limb fat in subjects continuing ZDV\/3TC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12011","type":"journal-article","created":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T18:11:21Z","timestamp":1357755081000},"page":"327-336","source":"Crossref","is-referenced-by-count":9,"title":["Impact of switching from zidovudine\/lamivudine to tenofovir\/emtricitabine on lipoatrophy: the RECOMB<\/scp> study"],"prefix":"10.1111","volume":"14","author":[{"given":"E","family":"Ribera","sequence":"first","affiliation":[{"name":"Infectious Diseases Division Hospital Universitari Vall d'Hebron Autonomous University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Larrousse","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Hospital Clinic\u2010IDIBAPS University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Curran","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division Hospital Universitari Vall d'Hebron Autonomous University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Negredo","sequence":"additional","affiliation":[{"name":"IrsiCaixa Foundation Institut Germans Trias i Pujol Diseases Division Autonomous University of Barcelona Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Clotet","sequence":"additional","affiliation":[{"name":"IrsiCaixa Foundation Institut Germans Trias i Pujol Diseases Division Autonomous University of Barcelona Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Estrada","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Sanz","sequence":"additional","affiliation":[{"name":"Hospital Universitario de la Princesa Instituto de Investigaci\u00f3n Princesa Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Berenguer","sequence":"additional","affiliation":[{"name":"Infectious Diseases\/HIV Unit Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Rubio","sequence":"additional","affiliation":[{"name":"Hospital Universitario 12 de Octubre Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Pulido","sequence":"additional","affiliation":[{"name":"Hospital Universitario 12 de Octubre Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Gilead Sciences SL Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ML","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Gilead Sciences SL Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Arterburn","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc. 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