{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T23:19:08Z","timestamp":1772234348128,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,2,24]],"date-time":"2013-02-24T00:00:00Z","timestamp":1361664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the study was to demonstrate the noninferiority of polyacrylamide hydrogel (<jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>) <jats:italic>vs.<\/jats:italic> polylactic acid (<jats:styled-content style=\"fixed-case\">PLA<\/jats:styled-content>) for the treatment of facial lipoatrophy in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized, blinded, multicentre, noninferiority 96\u2010week study was carried out. Patients with facial lipoatrophy were randomly assigned to receive intradermal injections with <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">PLA<\/jats:styled-content>, and were blinded to the filler. The primary efficacy endpoint was patient satisfaction at week 48 assessed using a visual analogue scale score (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>). Secondary efficacy end\u2010points included cheek thickness and skin\u2010fold, lipoatrophy grading and quality of life. Safety was assessed by the reporting of adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 148 patients were included in the study; 93% were men, the median age was 47 years, the median <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 count was 528 cells\/\u03bcL, and the median duration of antiretroviral therapy was 12 years. Mean <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> increased from 2.8 at baseline to 7.1 and 7.5 in the <jats:styled-content style=\"fixed-case\">PLA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> arms, respectively, at week 48 (<jats:italic>P<\/jats:italic>\u2009=\u20090.0002 for noninferiority) and was sustained at week 96 (6.7 and 7.9 in the <jats:styled-content style=\"fixed-case\">PLA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> arms, respectively; <jats:italic>P<\/jats:italic>\u2009=\u20090.003 for noninferiority). Cheek thickness and skin\u2010fold increases and lipoatrophy improvement were similar in the two arms. Quality of life remained unchanged or improved depending on the questionnaire used. In injected patients, subcutaneous nodules emerged in 28 (41%) and 26 (37%) patients in the <jats:styled-content style=\"fixed-case\">PLA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> arms, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.73). Four patients in the <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> arm developed severe inflammatory nodules, a median of 17 months after the last injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PLA<\/jats:styled-content> have similar efficacies in the treatment of facial lipoatrophy, but <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> may be associated with more delayed inflammatory nodules.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12021","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T01:36:37Z","timestamp":1361756197000},"page":"410-420","source":"Crossref","is-referenced-by-count":13,"title":["Polylactic acid <i>vs.<\/i> polyacrylamide hydrogel for treatment of facial lipoatrophy: a randomized controlled trial [<scp>A<\/scp>gence <scp>N<\/scp>ationale de <scp>R<\/scp>echerches sur le <scp>SIDA<\/scp> et les <scp>H<\/scp>\u00e9patites <scp>V<\/scp>irales (<scp>ANRS<\/scp>) 132 <scp>SMILE<\/scp>]"],"prefix":"10.1111","volume":"14","author":[{"given":"M","family":"Lafaurie","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Saint\u2010Louis Hospital  Paris France"},{"name":"University of Paris Diderot Paris 7  Sorbonne Paris Cit\u00e9 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Dolivo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Saint\u2010Louis Hospital  Paris France"},{"name":"University of Paris Diderot Paris 7  Sorbonne Paris Cit\u00e9 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u2010M","family":"Girard","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Saint\u2010Antoine Hospital  Paris France"},{"name":"University of Pierre\u2010et\u2010Marie\u2010Curie Paris\u2010VI  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"May","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Brabois Hospital Vandoeuvre les Nancy  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Bouchaud","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Avicenne Hospital  Bobigny Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Carbonnel","sequence":"additional","affiliation":[{"name":"Department of Dermatology E. 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