{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:12:36Z","timestamp":1765354356322},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T00:00:00Z","timestamp":1370390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2013,10]]},"abstract":"Objectives<\/jats:title>HIV<\/jats:styled-content> infection is associated with higher than expected cardiovascular event rates and lowered platelet counts. These conditions are associated with an elevation of mean platelet volume (MPV<\/jats:styled-content>). The present study compared MPV<\/jats:styled-content> in HIV<\/jats:styled-content>\u2010infected and uninfected women and identified factors influencing MPV<\/jats:styled-content> values in HIV<\/jats:styled-content>\u2010infected women.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 234 HIV<\/jats:styled-content>\u2010infected and 134 HIV<\/jats:styled-content>\u2010uninfected participants from the W<\/jats:styled-content>omen's I<\/jats:styled-content>nteragency HIV S<\/jats:styled-content>tudy (WIHS<\/jats:styled-content>) had MPV<\/jats:styled-content> values obtained. HIV<\/jats:styled-content>\u2010infected women were older, were more likely to have diabetes and had higher triglyceride levels than HIV<\/jats:styled-content>\u2010uninfected women.<\/jats:p><\/jats:sec>Results<\/jats:title>The mean platelet count was lower in HIV<\/jats:styled-content>\u2010infected vs.<\/jats:italic> uninfected women [249 cells\/\u03bcL (95% confidence interval (CI<\/jats:styled-content>) 238, 259 cells\/\u03bcL) vs.<\/jats:italic> 276 cells\/\u03bcL (95% CI<\/jats:styled-content> 265, 287 cells\/\u03bcL), respectively; P<\/jats:italic>\u2009<\u20090.01]. Adjusted mean MPV<\/jats:styled-content> values were lower in the HIV<\/jats:styled-content>\u2010infected than in the uninfected group [8.66 fL (95% CI<\/jats:styled-content> 8.52, 8.79 fL) vs.<\/jats:italic> 9.05 fL (95% CI<\/jats:styled-content> 8.87, 9.24 fL), respectively]. In multiple regression analysis, after adjusting for other covariates, MPV<\/jats:styled-content> was positively associated with platelet count, and negatively with HIV<\/jats:styled-content> infection (model R<\/jats:styled-content><\/jats:italic>2<\/jats:sup>\u2009=\u20090.20; P<\/jats:italic>\u2009<\u20090.01). In multiple regression analysis confined to HIV<\/jats:styled-content>\u2010infected women, a lower MPV<\/jats:styled-content> was independently associated with a history of AIDS<\/jats:styled-content>\u2010defining illness (R<\/jats:styled-content><\/jats:italic>2<\/jats:sup>\u2009=\u20090.28; P<\/jats:italic>\u2009=\u20090.03), but not with nadir CD<\/jats:styled-content>4 count or highly active antiretroviral therapy (HAART<\/jats:styled-content>) use.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>HIV<\/jats:styled-content>\u2010infected women had lower MPV<\/jats:styled-content> values than uninfected women, suggesting impaired production rather than increased destruction. Higher than expected cardiovascular event rates cannot be attributed to greater platelet reactivity as measured by MPV<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12048","type":"journal-article","created":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T03:17:59Z","timestamp":1370488679000},"page":"549-555","source":"Crossref","is-referenced-by-count":8,"title":["Mean platelet volume is decreased in HIV<\/scp>\u2010infected women"],"prefix":"10.1111","volume":"14","author":[{"given":"S","family":"Qadri","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine State University of New York, Downstate Medical Center Brooklyn NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Holman","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine & Community Health State University of New York, Downstate Medical Center Brooklyn NY 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