{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T06:11:51Z","timestamp":1696399911839},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,9,6]],"date-time":"2013-09-06T00:00:00Z","timestamp":1378425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Interleukin\u20102 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102) therapy increased <jats:styled-content style=\"fixed-case\">CD4<\/jats:styled-content> cell counts and delayed antiretroviral therapy (<jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>) initiation in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients in the <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>gence <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ationale de <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>echerche sur le <jats:styled-content style=\"fixed-case\">SIDA<\/jats:styled-content> et les H\u00e9patites Virales (<jats:styled-content style=\"fixed-case\">ANRS<\/jats:styled-content>) 119 trial. However, four cases of lymphoma were reported. <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>pstein\u2212<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>arr virus (<jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>) replication is associated with an increased risk of lymphoma in immunocompromised patients. We assessed whether <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102 had an impact on <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> replication and the development of lymphoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 130 <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>\u2010na\u00efve patients were randomized to receive <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102 therapy (<jats:italic>n<\/jats:italic>\u2009=\u200966) or no treatment (<jats:italic>n<\/jats:italic>\u2009=\u200964). Clinical data for patients with lymphomas were reviewed and tumours assessed for evidence of <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> infection and <jats:styled-content style=\"fixed-case\">CD25<\/jats:styled-content> (the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102 receptor) expression. <jats:styled-content style=\"fixed-case\">EBV DNA<\/jats:styled-content> levels were measured in whole blood and plasma in both arms using real\u2010time polymerase chain reaction (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>), up to 48 weeks after baseline (<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four lymphomas occurred, a median of 61 weeks [range 40\u221294 weeks] after randomization at a median <jats:styled-content style=\"fixed-case\">CD4<\/jats:styled-content> cell count of 396 cells\/\u03bcL (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 234\u2013536 cells\/\u03bcL). In the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102 arm, two patients developed <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010positive Hodgkin's lymphoma, and one developed <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010negative Burkitt\u2010type lymphoma. One patient in the control group developed <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010positive non\u2010Hodgkin's lymphoma. <jats:styled-content style=\"fixed-case\">CD25<\/jats:styled-content> was negative in all cases. Among the 41 of 55 (control arm) and 44 of 58 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102 arm) patients with detectable <jats:styled-content style=\"fixed-case\">EBV DNA<\/jats:styled-content> in whole blood at both <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> and week 48, the median change in <jats:styled-content style=\"fixed-case\">EBV DNA<\/jats:styled-content> between <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> and week 48 was +0.04 log<jats:sub>10<\/jats:sub> copies\/ml in both arms (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.7). In plasma, <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> was detected at least once in 22 of 52 controls and 21 of 54 <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102\u2010treated patients (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.8).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102 therapy had no significant effect on <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> replication over 48 weeks in these <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>\u2010na\u00efve patients. The occurrence of lymphomas did not seem to be associated with <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102 therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12077","type":"journal-article","created":{"date-parts":[[2013,9,6]],"date-time":"2013-09-06T08:01:29Z","timestamp":1378454489000},"page":"23-29","source":"Crossref","is-referenced-by-count":4,"title":["Lymphoma and <scp>E<\/scp>pstein\u2212<scp>B<\/scp>arr virus <scp>DNA<\/scp> in blood during interleukin\u20102 therapy in antiretroviral\u2010na\u00efve <scp>HIV<\/scp>\u20101\u2010infected patients: a substudy of the <scp>ANRS<\/scp> 119 trial"],"prefix":"10.1111","volume":"15","author":[{"given":"V","family":"de Lastours","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Saint\u2010Louis Hospital  Paris France"},{"name":"University Paris Diderot Sorbonne Paris Cit\u00e9  Paris 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