{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T11:15:42Z","timestamp":1769858142521,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T00:00:00Z","timestamp":1380067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Objectives<\/jats:title>Mortality in young people with perinatally acquired HIV<\/jats:styled-content> infection (PHIV<\/jats:styled-content>) following transfer to adult care has not been characterized in the UK<\/jats:styled-content>. We conducted a multicentre audit to establish the number of deaths and associated factors.<\/jats:p><\/jats:sec>Methods<\/jats:title>Fourteen adult clinics caring for infected young people reported deaths to 30 S<\/jats:styled-content>eptember 2011 on a proforma. Deaths were matched to the Collaborative HIV<\/jats:styled-content> Paediatric Study, a clinical database of HIV<\/jats:styled-content>\u2010infected children in the UK<\/jats:styled-content>\/I<\/jats:styled-content>reland, to describe clinical characteristics in paediatric care of those who died post\u2010transition.<\/jats:p><\/jats:sec>Results<\/jats:title>Eleven deaths were reported from 14 clinics which cared for 248 adults with PHIV<\/jats:styled-content>. For the 11 deaths, the median age at transfer to adult care was 17 years (range 15\u201321 years), and at death was 21 years (range 17\u201324 years). Causes of death were suicide (two patients), advanced HIV<\/jats:styled-content> disease (seven patients) and bronchiectasis (one patient), with one cause missing. At death, the median CD<\/jats:styled-content>4 count was 27 cells\/\u03bcL (range 0\u2013630 cells\/\u03bcL); five patients were on antiretroviral therapy (ART<\/jats:styled-content>) but only two had a viral load <\u200950 HIV<\/jats:styled-content>\u20101 RNA<\/jats:styled-content> copies\/mL. Nine had poor adherence when in paediatric care, continuing into adult care despite multidisciplinary support. Eight had ART<\/jats:styled-content> resistance, although all had potentially suppressive regimens available. Nine had mental health diagnoses.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our findings highlight the complex medical and psychosocial issues faced by some adults with PHIV<\/jats:styled-content>, with nine of the 11 deaths in our study being associated with poor adherence and advanced HIV<\/jats:styled-content> disease. Novel adherence interventions and mental health support are required for this vulnerable cohort.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12091","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T21:04:35Z","timestamp":1381525475000},"page":"239-244","source":"Crossref","is-referenced-by-count":93,"title":["Mortality in perinatally HIV<\/scp>\u2010infected young people in E<\/scp>ngland following transition to adult care: an HIV Y<\/scp>oung P<\/scp>ersons N<\/scp>etwork (HYPNet<\/scp>) audit"],"prefix":"10.1111","volume":"15","author":[{"given":"R","family":"Fish","sequence":"first","affiliation":[{"name":"TEAM Clinic, Mortimer Market Centre Central Northwest London NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Judd","sequence":"additional","affiliation":[{"name":"Medical Research Council Clinical Trials Unit London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Jungmann","sequence":"additional","affiliation":[{"name":"TEAM Clinic, Mortimer Market Centre Central Northwest London NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"O'Leary","sequence":"additional","affiliation":[{"name":"Medical Research Council Clinical Trials Unit London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Foster","sequence":"additional","affiliation":[{"name":"The 900 Clinic Imperial College Healthcare NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"HIV Young Persons Network (HYPNet)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7422.1019"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2008.0153"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540120600581460"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2011.0178"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/521167"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2441"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2012.668174"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181d90e8c"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2009.0198"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2011.575120"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0B013E31822D7564"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32834dcec9"},{"key":"e_1_2_6_14_1","volume-title":"Death Registration Summary Statistics, England and Wales","author":"Office for National Statistics","year":"2010"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000179459.31562.16"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.8-3-250"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2009.0081"},{"key":"e_1_2_6_18_1","unstructured":"KentA FosterC FidlerS.How do patterns of antiretroviral adherence in childhood impact on adherence in adult life?17th Annual Conference of the British HIV Association. 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