{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T22:26:44Z","timestamp":1784932004517,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T00:00:00Z","timestamp":1381881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Because of the improved life expectancy provided by successful antiretroviral combination therapy, preventive health measures in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients have assumed increasing importance. To date, no data exist on rates of mucosal abnormalities detected by screening colonoscopy in &gt;\u200950\u2010year\u2010old <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients in <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ermany. The aim of this study was to obtain such data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A screening colonoscopy was offered to 159 <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients (age\u2009&gt;\u200950 years) who presented for <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> standard of care visits at the infectious diseases out\u2010patient clinic at the university hospital in <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>onn over a 1\u2010year period from <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ebruary 2010. <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>earson's \u03c7<jats:sup>2<\/jats:sup> test, Fisher's exact test and the <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ann\u2212<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>hitney <jats:italic><jats:styled-content style=\"fixed-case\">U<\/jats:styled-content><\/jats:italic>\u2010test were used for statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010one patients (32.1%) had undergone a screening colonoscopy in the past 10 years, and 45 patients (28.3%) were eventually screened in the observation period. The median age of the 96 screened patients (86% male and 14% female) was 58 years [interquartile range (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>) 54\u201364 years]. Overall, endoscopic abnormalities were found in 61% of patients. Histological examination showed tubular adenomas in 21.9% of patients, tubulovillous adenomas in 3.1% and serrated adenomas in 1%. Hyperplastic polyps were found in 15.6% of patients, a nonspecific colitis in 16.7% and diverticulosis in 12.5%. In four cases there was even an early\u2010stage carcinoma (two anal, one rectal and one colon cancer). In univariate analysis, no significant differences with regard to immune status, highly active antiretroviral therapy, family history, personal risk factors or comedication were found between patients with dysplastic and normal mucosas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The high acceptance rate of screening colonoscopy and the in comparison with the <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010negative population comparably higher rate of abnormalities in this cohort of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients justify enhanced implementation of screening colonoscopy in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12098","type":"journal-article","created":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T08:27:07Z","timestamp":1381912027000},"page":"175-181","source":"Crossref","is-referenced-by-count":11,"title":["Screening colonoscopy in <scp>HIV<\/scp>\u2010infected patients: high rates of mucosal abnormalities in a <scp>G<\/scp>erman <scp>HIV<\/scp>\u2010infected cohort"],"prefix":"10.1111","volume":"15","author":[{"given":"A","family":"Kasapovic","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I Bonn University Hospital  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Boesecke","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Bonn University Hospital  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Schwarze\u2010Zander","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Bonn University Hospital  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Anadol","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Bonn University Hospital  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Vogel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Bonn University Hospital  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Hippe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Bonn University Hospital  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Bonn University Hospital  Bonn Germany"},{"name":"Department of Internal Medicine St Marienw\u00f6rth Hospital  Bad Kreuznach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JK","family":"Rockstroh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Bonn University Hospital  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JC","family":"Wasmuth","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Bonn University Hospital  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,16]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Robert Koch\u2010Institut.Krebs in Deutschland 2005\/2006. 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