{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:29:57Z","timestamp":1790206197374,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T00:00:00Z","timestamp":1391990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["M01 RR000865, K24 AI56933, P30 AG028748, T32 MH080634"],"award-info":[{"award-number":["M01 RR000865, K24 AI56933, P30 AG028748, T32 MH080634"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck & Co., Inc.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000085","name":"Ontario HIV Treatment Network","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000085","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Merck Canada, Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2014,8]]},"abstract":"\n Objectives<\/jats:title>\n \n Soluble\n CD14<\/jats:styled-content>\n (\n sCD14<\/jats:styled-content>\n ) is a monocyte activation marker associated with increased mortality in\n HIV<\/jats:styled-content>\n infection. We assessed 48\u2010week changes in\n sCD14<\/jats:styled-content>\n and other inflammatory biomarkers in virologically suppressed,\n HIV<\/jats:styled-content>\n \u2010infected women switching to raltegravir (\n RAL<\/jats:styled-content>\n ) from a protease inhibitor (\n PI<\/jats:styled-content>\n ) or nonnucleoside reverse transcriptase inhibitor (\n NNRTI<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n HIV<\/jats:styled-content>\n \u2010infected women with central adiposity and\n HIV<\/jats:styled-content>\n \u20101\n RNA<\/jats:styled-content>\n <\u200950\n HIV<\/jats:styled-content>\n \u20101\n RNA<\/jats:styled-content>\n copies\/mL continued their thymidine\u2010sparing nucleoside reverse transcriptase inhibitor (\n NRTI<\/jats:styled-content>\n ) backbone and were randomized to switch to open\u2010label\n RAL<\/jats:styled-content>\n at week 0 (immediate) or 24 (delayed). In an exploratory analysis, inflammatory biomarkers were measured on stored fasting plasma.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 37 evaluable subjects, 78% were non\u2010\n W<\/jats:styled-content>\n hite; the median age was 43 years, the median body mass index (\n BMI<\/jats:styled-content>\n ) was 32\u2009kg\/m\n 2<\/jats:sup>\n and the median\n CD<\/jats:styled-content>\n 4 count was 558\u2009cells\/\u03bcL. At baseline, biomarker values were similar between groups. After 24 weeks, median\n sCD14<\/jats:styled-content>\n significantly declined in subjects switching to\n RAL<\/jats:styled-content>\n [\u221221% (\n P<\/jats:italic>\n \u2009<\u20090.001)\n vs.<\/jats:italic>\n \u2005\n PI<\/jats:styled-content>\n \/\n NNRTI<\/jats:styled-content>\n \u22125% (\n P<\/jats:italic>\n \u2009=\u20090.49); between\u2010group\n P<\/jats:italic>\n \u2009<\u20090.01]. After 48 weeks, immediate\u2010switch subjects maintained this decline and delayed\u2010switch subjects experienced a similar decline following the switch to\n RAL<\/jats:styled-content>\n (\u221210%; within\u2010group\n P<\/jats:italic>\n \u2009<\u20090.01). Immediate\u2010switch subjects also experienced an initial increase in tumour necrosis factor (\n TNF<\/jats:styled-content>\n )\u2010\u03b1 that was neither maintained after 48 weeks nor seen in delayed\u2010switch subjects. After adjustment for multiple testing, only declines in\n sCD14<\/jats:styled-content>\n remained significant.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In this randomized trial of women with central adiposity, a switch to\n RAL<\/jats:styled-content>\n from a\n PI<\/jats:styled-content>\n or\n NNRTI<\/jats:styled-content>\n was associated with a statistically significant decline in\n sCD14<\/jats:styled-content>\n . Further studies are needed to determine whether integrase inhibitors have improved monocyte activation profiles compared with\n PIs<\/jats:styled-content>\n and\/or\n NNRTIs<\/jats:styled-content>\n , and whether measured differences between antiretroviral agents translate to demonstrable clinical benefit.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hiv.12128","type":"journal-article","created":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T01:06:45Z","timestamp":1391994405000},"page":"431-441","source":"Crossref","is-referenced-by-count":37,"title":["Switch to raltegravir decreases soluble\n CD14<\/scp>\n in virologically suppressed overweight women: the\n W<\/scp>\n omen,\n I<\/scp>\n ntegrase and\n F<\/scp>\n at\n A<\/scp>\n ccumulation\n T<\/scp>\n rial"],"prefix":"10.1111","volume":"15","author":[{"given":"JE","family":"Lake","sequence":"first","affiliation":[{"name":"Department of Medicine University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GA","family":"McComsey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Medicine Case Western Reserve University Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Hulgan","sequence":"additional","affiliation":[{"name":"Department of Medicine Vanderbilt University Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CA","family":"Wanke","sequence":"additional","affiliation":[{"name":"Department of Medicine Tufts University Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Mangili","sequence":"additional","affiliation":[{"name":"Department of Medicine Tufts University Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SL","family":"Walmsley","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SA","family":"Stramotas","sequence":"additional","affiliation":[{"name":"University of California Riverside CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Tracy","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Vermont Burlington VT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JS","family":"Currier","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California Los Angeles CA 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