{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:31:25Z","timestamp":1787841085585,"version":"build-2784847793"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,9,6]],"date-time":"2014-09-06T00:00:00Z","timestamp":1409961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R24 AI067039-01A1"],"award-info":[{"award-number":["R24 AI067039-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008673","name":"Clinical Investigation Core of the University of California San Diego Center for AIDS Research","doi-asserted-by":"crossref","award":["AI036214"],"award-info":[{"award-number":["AI036214"]}],"id":[{"id":"10.13039\/100008673","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2015,3]]},"abstract":"Objectives<\/jats:title>The aim of the study was to estimate the cumulative incidence of, and rates of progression to, invasive anal cancer (IAC<\/jats:styled-content>) according to baseline anal cytology screening category in an unselected HIV<\/jats:styled-content> clinical care cohort in the antiretroviral era.<\/jats:p><\/jats:sec>Methods<\/jats:title>A retrospective cohort analysis of HIV<\/jats:styled-content>\u2010infected patients under care at the U<\/jats:styled-content>niversity of C<\/jats:styled-content>alifornia at S<\/jats:styled-content>an D<\/jats:styled-content>iego O<\/jats:styled-content>wen C<\/jats:styled-content>linic was carried out. Patients were eligible for this analysis if they had at least two anal cytohistological results available for longitudinal analysis. K<\/jats:styled-content>aplan\u2212M<\/jats:styled-content>eier analysis was used to estimate the cumulative incidence of IAC<\/jats:styled-content> over time according to baseline cytology category [less than high\u2010grade intraepithelial lesion (HSIL<\/jats:styled-content>) versus HSIL<\/jats:styled-content>]. Cox regression analysis was used to adjust for the following covariates: antiretroviral use, level of HIV<\/jats:styled-content> viraemia, smoking status and infrared photocoagulation (IRC<\/jats:styled-content>) ablation therapy.<\/jats:p><\/jats:sec>Results<\/jats:title>Between 2000 and 2012, we followed 2804 HIV<\/jats:styled-content>\u2010infected patients for a median of 4 years under a clinic protocol requiring baseline anal cytology screening. Incident IAC<\/jats:styled-content> was diagnosed in 23 patients. Patients with a baseline HSIL<\/jats:styled-content> anal cytology had an estimated 5\u2010year probability of progression to IAC<\/jats:styled-content> of 1.7% and an estimated annual progression risk of 1 in 263. None of the examined covariates was significantly associated with IAC<\/jats:styled-content> incidence when examined in separate unadjusted Cox models.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>HIV<\/jats:styled-content>\u2010infected patients with a baseline HSIL<\/jats:styled-content> anal cytology had a 5\u2010year cumulative incidence of IAC<\/jats:styled-content> of 1.65%, with an upper 95% confidence bound of 4.5%. This population\u2010based study provides quantitative risk estimates that may be used for counselling patients regarding management options for abnormal cytology results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12190","type":"journal-article","created":{"date-parts":[[2014,9,6]],"date-time":"2014-09-06T06:25:10Z","timestamp":1409984710000},"page":"191-195","source":"Crossref","is-referenced-by-count":33,"title":["Five\u2010year cumulative incidence of invasive anal cancer among HIV<\/scp>\u2010infected patients according to baseline anal cytology results: an inception cohort analysis"],"prefix":"10.1111","volume":"16","author":[{"given":"E","family":"Cachay","sequence":"first","affiliation":[{"name":"Department of Medicine University of California at San Diego San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Agmas","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California at San Diego San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Mathews","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California at San Diego San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,6]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"122","article-title":"Human papillomavirus, anal cancer, and screening considerations among HIV\u2010infected individuals","volume":"15","author":"Cachay ER","year":"2013","journal-title":"AIDS Rev"},{"key":"e_1_2_6_3_1","unstructured":"Available athttp:\/\/id.medicine.ucsf.edu\/analcancerinfo\/providers.html(accessed 21 February 2014)."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1071\/SH12045"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70080-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e31825c31dd"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28431"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2006.03837.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4994"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0229-z"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000160"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-13-946"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024946"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012284"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70103-7"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhiv.12190","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.12190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T11:51:30Z","timestamp":1696247490000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.12190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,6]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/hiv.12190"],"URL":"https:\/\/doi.org\/10.1111\/hiv.12190","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,6]]}}}