{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:20:47Z","timestamp":1761744047722,"version":"3.28.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,12,18]],"date-time":"2014-12-18T00:00:00Z","timestamp":1418860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Objectives<\/jats:title>The aim of the study was to determine the prevalence of potential clinically significant drug interactions (CSDI<\/jats:styled-content>s) in HIV\u2010positive individuals and to identify associated risk factors.<\/jats:p><\/jats:sec>Methods<\/jats:title>A cross\u2010sectional study was conducted including all HIV<\/jats:styled-content>\u2010infected out\u2010patients attending the Pharmacy Service of a regional reference hospital in Murcia, south\u2010eastern S<\/jats:styled-content>pain. The complete treatment was screened for possible CSDI<\/jats:styled-content>s using the Spanish College of Pharmacists' online software resource, bot<\/jats:sc>. Additionally, the severity level of the CSDI<\/jats:styled-content>s involving antiretroviral (ARV<\/jats:styled-content>) drugs was compared with that established in the specific antiretroviral database InteraccionesHIV.com. Multivariate logistic regression was used to identify associated risk factors.<\/jats:p><\/jats:sec>Results<\/jats:title>Two hundred and sixty\u2010eight patients were included in the study. A total of 292 potential drug interactions were identified, of which 102 (34.9%) were CSDI<\/jats:styled-content>s, of which 52.9% involved ARV<\/jats:styled-content> drugs. Seven therapeutic drug classes were involved in 75% of CSDI<\/jats:styled-content>s (protease inhibitors, benzodiazepines, nonsteroidal anti\u2010inflammatory drugs, nonnucleoside reverse transcriptase inhibitors, corticosteroids, antithrombotics and proton pump inhibitors). Factors independently associated with CSDI<\/jats:styled-content>s were treatment with more than five drugs [odds ratio (OR<\/jats:styled-content>) 15.1; 95% confidence interval (CI<\/jats:styled-content>) 6.3\u201336.2], and treatment with a protease inhibitor (OR<\/jats:styled-content> 5.3; 95% CI<\/jats:styled-content> 2.4\u201311.74).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The findings of this study suggest that the prevalence of clinically relevant drug\u2212drug interactions is high in HIV<\/jats:styled-content>\u2010infected patients, and could represent a major health problem. Awareness, recognition and management of drug interactions are important in optimizing the pharmaceutical care of HIV<\/jats:styled-content>\u2010infected patients and helping to prevent adverse events and\/or loss of efficacy of the drugs administered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12205","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T09:00:19Z","timestamp":1418979619000},"page":"273-279","source":"Crossref","is-referenced-by-count":21,"title":["Identification of potential clinically significant drug interactions in HIV<\/scp>\u2010infected patients: a comprehensive therapeutic approach"],"prefix":"10.1111","volume":"16","author":[{"given":"C","family":"Iniesta\u2010Naval\u00f3n","sequence":"first","affiliation":[{"name":"Department of Hospital Pharmacy Queen Sofia Hospital of Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JJ","family":"Franco\u2010Miguel","sequence":"additional","affiliation":[{"name":"Department of Hospital Pharmacy Queen Sofia Hospital of Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JJ","family":"Gasc\u00f3n\u2010C\u00e1novas","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Rentero\u2010Redondo","sequence":"additional","affiliation":[{"name":"Department of Hospital Pharmacy Queen Sofia Hospital of Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028013504075"},{"key":"e_1_2_6_3_1","unstructured":"APEAS Study Patient Safety in Primary Health Care.Ministry of health and consumer affairs.2008. Available athttp:\/\/www.msssi.gob.es\/organizacion\/sns\/planCalidadSNS\/docs\/estudio_apeas.pdf(accesed 18 October 2013)."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.27.10.1379"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2003.00541.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.31.5.480"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61092-7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/652149"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200241140-00004"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks346"},{"key":"e_1_2_6_11_1","unstructured":"Consejo General del Colegio Oficial de Farmac\u00e9uticos.Base de datos del medicamento del Colegio Oficial de Farmac\u00e9uticos de Espa\u00f1a (BOT). Enero2013."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1130-6343(09)71155-9"},{"key":"e_1_2_6_13_1","unstructured":"Instituto de Investigaciones Biom\u00e9dicas Augusti Pi i Sunyer.InteraccionesHIV.2012. Available athttp:\/\/www.interaccioneshiv.com(accesed January 2013)."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1540"},{"key":"e_1_2_6_15_1","first-page":"273","article-title":"Prevalence of antiretroviral interactions with concomitant treatment, medicinal plants, drugs and alcohol","volume":"15","author":"Bonaga Serrano B","year":"2013","journal-title":"Aten Farm"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1P576"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-006-0122-2"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.6.2091-2096.2004"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-007-0344-y"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12695"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-013-2449-6"},{"key":"e_1_2_6_22_1","first-page":"749","article-title":"Polypharmacy in the HIV\u2010infected older adult population","volume":"8","author":"Gleason LJ","year":"2013","journal-title":"Clin Interv Aging"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2009.12.019"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835584ea"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2008.00930.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2011.00915.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp070072"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1197\/jamia.M1809"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhiv.12205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.12205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T07:27:33Z","timestamp":1729582053000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.12205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,18]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/hiv.12205"],"URL":"https:\/\/doi.org\/10.1111\/hiv.12205","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"type":"print","value":"1464-2662"},{"type":"electronic","value":"1468-1293"}],"subject":[],"published":{"date-parts":[[2014,12,18]]}}}