{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T14:06:40Z","timestamp":1749823600572,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004263","name":"FAPERGS","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Secretaria Nacional de DST, Aids e hepatites virais"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Objectives<\/jats:title>Adiponectin is a circulating peptide secreted by mature adipocytes that may act as a regulator of glucose and lipid metabolism. This study aimed to investigate the association between genetic variability in the adiponectin receptor genes ADIPOR1<\/jats:italic><\/jats:styled-content> (adiponectin receptor 1) and ADIPOR2<\/jats:italic><\/jats:styled-content> and lipodystrophy and its related anthropometric and metabolic phenotypes in HIV<\/jats:styled-content>\u2010infected patients on highly active antiretroviral therapy (HAART<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>We studied six single nucleotide polymorphisms (SNPs<\/jats:styled-content>) in the adiponectin receptor genes ADIPOR1<\/jats:italic><\/jats:styled-content> (rs1342387 and rs10920533) and ADIPOR2<\/jats:italic><\/jats:styled-content> (rs11061925, rs10773983, rs929434 and rs767870) and their association with adiponectin plasma levels, lipodystrophy subtypes and other parameters linked to glucose and lipid metabolism involved in the lipodystrophic syndrome. The genotypes of 407 HIV<\/jats:styled-content>\u2010infected patients receiving HAART<\/jats:styled-content> were investigated using real\u2010time polymerase chain reaction. Mean biochemical and anthropometrical parameters were compared between the different genotypes using analysis of variance.<\/jats:p><\/jats:sec>Results<\/jats:title>Two ADIPOR2<\/jats:italic> SNPs<\/jats:styled-content> (rs11061925 and rs929434) were associated with fasting plasma triglyceride concentrations in the entire sample. Stronger significant associations were found between these SNPs<\/jats:styled-content> and biochemical parameters (levels of triglycerides, total cholesterol, adiponectin and glucose) in men. We did not find any significant associations with ADIPOR1<\/jats:italic><\/jats:styled-content> gene variants.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>SNPs<\/jats:styled-content> in the ADIPOR2<\/jats:italic><\/jats:styled-content> gene appear to be involved in the metabolic alterations in HIV<\/jats:styled-content>\u2010infected men receiving HAART<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12250","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T09:59:48Z","timestamp":1435226388000},"page":"494-501","source":"Crossref","is-referenced-by-count":10,"title":["Polymorphisms in adiponectin receptor genes are associated with lipodystrophy\u2010related phenotypes in HIV<\/scp>\u2010infected patients receiving antiretroviral therapy"],"prefix":"10.1111","volume":"16","author":[{"given":"JK","family":"Castilhos","sequence":"first","affiliation":[{"name":"Graduate Program in Pathology Federal University of Health Sciences of Porto Alegre Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Sprinz","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre Federal University of Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RK","family":"Lazzaretti","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre Federal University of Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Kuhmmer","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre Federal University of Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2697-4909","authenticated-orcid":false,"given":"VS","family":"Mattevi","sequence":"additional","affiliation":[{"name":"Graduate Program in Pathology Federal 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