{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:17:55Z","timestamp":1790428675872,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"European AIDS Treatment Network (NEAT)","award":["001\/ANRS143"],"award-info":[{"award-number":["001\/ANRS143"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2015,11]]},"abstract":"Objectives<\/jats:title>Monocyte activation, endothelial dysfunction and platelet activation all potentially contribute to the increased risk of cardiovascular disease (CVD<\/jats:styled-content>) reported in those with HIV<\/jats:styled-content>\u20101 infection. To date, no study has examined how initiation of antiretroviral therapy (ART<\/jats:styled-content>) affects markers of all three processes. We aimed to compare markers of monocyte, endothelial and platelet function between untreated HIV<\/jats:styled-content>\u2010positive subjects and HIV<\/jats:styled-content>\u2010negative controls and to examine the early effects of ART<\/jats:styled-content> initiation on these markers.<\/jats:p><\/jats:sec>Methods<\/jats:title>We measured monocyte [soluble CD14<\/jats:styled-content> (sCD14<\/jats:styled-content>) and sCD163<\/jats:styled-content>], endothelial [von W<\/jats:styled-content>illebrand factor (vWF<\/jats:styled-content>), intercellular adhesion molecule\u20101 (ICAM<\/jats:styled-content>\u20101) and vascular adhesion molecule\u20101 (VCAM<\/jats:styled-content>\u20101)] and platelet [soluble P<\/jats:styled-content>\u2010selectin (sP<\/jats:styled-content>\u2010selectin), soluble CD40<\/jats:styled-content> ligand (sCD40L<\/jats:styled-content>) and soluble glycoprotein VI<\/jats:styled-content> (sGPVI<\/jats:styled-content>)] biomarkers before and at weeks 4 and 12 post ART<\/jats:styled-content> initiation in HIV<\/jats:styled-content>\u2010positive and well\u2010matched HIV<\/jats:styled-content>\u2010negative controls.<\/jats:p><\/jats:sec>Results<\/jats:title>We examined 40 subjects, 25 HIV<\/jats:styled-content>\u2010positive subjects and 15 controls, with a median age of 34 years [interquartile range (IQR<\/jats:styled-content>) 31, 40 years], of whom 60% were male and 47.5% C<\/jats:styled-content>aucasian. P<\/jats:styled-content>re\u2010ART<\/jats:styled-content>, all biomarkers (monocyte, endothelial and platelet) were significantly higher in HIV<\/jats:styled-content>\u2010positive patients versus controls (all P<\/jats:italic>\u2009<\u20090.05) and decreased with ART<\/jats:styled-content> initiation, except for sCD14<\/jats:styled-content>, which remained unchanged [median 1680 (IQR<\/jats:styled-content> 1489, 1946) ng\/mL at week 12 versus 1570 (IQR<\/jats:styled-content> 1287, 2102) ng\/mL at week 0; P<\/jats:italic>\u2009=\u20090.7]. Although platelet activation markers reduced to levels comparable to those in controls, endothelial dysfunction markers remained elevated, as did sCD<\/jats:styled-content>163 [at week 12, median 1005 (IQR<\/jats:styled-content> 791, 1577) ng\/mL in HIV<\/jats:styled-content>\u2010positive patients versus 621 (IQR<\/jats:styled-content> 406, 700) ng\/mL in controls; P<\/jats:italic>\u2009<\u20090.0001].<\/jats:p><\/jats:sec>Conclusions<\/jats:title>ART<\/jats:styled-content> initiation resulted in reductions in levels of CVD<\/jats:styled-content>\u2010associated biomarkers; however, although they improved, markers of endothelial dysfunction and monocyte activation remained elevated. How these persistent abnormalities affect CVD<\/jats:styled-content> risk in HIV<\/jats:styled-content> infection remains to be determined.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12270","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T10:03:20Z","timestamp":1435226600000},"page":"608-619","source":"Crossref","is-referenced-by-count":67,"title":["The effect of initiation of antiretroviral therapy on monocyte, endothelial and platelet function in HIV<\/scp>\u20101 infection"],"prefix":"10.1111","volume":"16","author":[{"given":"JA","family":"O'Halloran","sequence":"first","affiliation":[{"name":"HIV Molecular Research Group School of Medicine and Medical Science University College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Dunne","sequence":"additional","affiliation":[{"name":"Cardiovascular Biology Group Royal College of Surgeons in Ireland Dublin 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