{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T22:59:57Z","timestamp":1762210797183},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,6,8]],"date-time":"2015-06-08T00:00:00Z","timestamp":1433721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Danish Medical Women\u2019s Association (Grant of Agnethe L\u00f8vgreen)","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"name":"the Aragon Foundation","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"name":"The Foundation of Aase and Ejnar Danielsens","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Objectives<\/jats:title>Women living with HIV<\/jats:styled-content> (WLWH<\/jats:styled-content>) are reportedly at increased risk of invasive cervical cancer (ICC<\/jats:styled-content>). A recent publication found that WLWH<\/jats:styled-content> in D<\/jats:styled-content>enmark attend the national ICC<\/jats:styled-content> screening programme less often than women in the general population. We aimed to estimate the incidence of cervical dysplasia and ICC<\/jats:styled-content> in WLWH<\/jats:styled-content> in D<\/jats:styled-content>enmark compared with that in women in the general population.<\/jats:p><\/jats:sec>Methods<\/jats:title>We studied a nationwide cohort of WLWH<\/jats:styled-content> and a cohort of 15 age\u2010matched women per WLWH<\/jats:styled-content> from the general population for the period 1999\u20132010. Pathology samples were obtained from The D<\/jats:styled-content>anish P<\/jats:styled-content>athology D<\/jats:styled-content>ata B<\/jats:styled-content>ank, which contains nationwide records of all pathology specimens. The cumulative incidence and hazard ratios (HRs<\/jats:styled-content>) for time from inclusion to first cervical intraepithelial neoplasia (CIN<\/jats:styled-content>)\/ICC<\/jats:styled-content> and time from first normal cervical cytology result to first CIN<\/jats:styled-content>\/ICC<\/jats:styled-content> were estimated. Sensitivity analyses were performed to include prior screening outcome, screening intensity and treatment of CIN<\/jats:styled-content>\/ICC<\/jats:styled-content> in the interpretation of results.<\/jats:p><\/jats:sec>Results<\/jats:title>We followed 1140 WLWH<\/jats:styled-content> and 17\u2009046 controls with no prior history of ICC<\/jats:styled-content> or hysterectomy for 9491 and 156\u2009865 person\u2010years, respectively. Compared with controls, the overall incidences of CIN1<\/jats:styled-content> or worse (CIN1<\/jats:styled-content>+), CIN2<\/jats:styled-content>+ and CIN3<\/jats:styled-content>+, but not ICC<\/jats:styled-content>, were higher in WLWH<\/jats:styled-content> and predicted by young age and a CD4<\/jats:styled-content> count <\u2009200\u2009cells\/\u03bcL. In women with normal baseline cytology, incidences of CIN1<\/jats:styled-content>+ and CIN2<\/jats:styled-content>+ were higher in WLWH<\/jats:styled-content>. However, when we compared subgroups of WLWH<\/jats:styled-content> and controls where women in both groups were adherent to the national ICC<\/jats:styled-content> screening programme and had a normal baseline cytology, incidences of CIN<\/jats:styled-content> and ICC<\/jats:styled-content> were comparable.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Overall, WLWH<\/jats:styled-content> developed more cervical disease than controls. Yet, in WLWH<\/jats:styled-content> and controls adherent to the national ICC<\/jats:styled-content> screening programme and with normal baseline cytology, incidences of CIN<\/jats:styled-content> and ICC<\/jats:styled-content> were comparable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12271","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T22:04:34Z","timestamp":1433973874000},"page":"7-17","source":"Crossref","is-referenced-by-count":20,"title":["Incidence of cervical dysplasia and cervical cancer in women living with HIV<\/scp> in D<\/scp>enmark: comparison with the general population"],"prefix":"10.1111","volume":"17","author":[{"given":"K","family":"Thorsteinsson","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Hvidovre Hospital, University of Copenhagen Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Ladelund","sequence":"additional","affiliation":[{"name":"Clinical Research Center Hvidovre Hospital, University of Copenhagen Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Jensen\u2010Fangel","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Skejby Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TL","family":"Katzenstein","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The National University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I Somuncu","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Junge","sequence":"additional","affiliation":[{"name":"Department of Pathology Hvidovre Hospital University of Copenhagen Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Helleberg","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The National University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Storgaard","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Skejby Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Obel","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The National University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A\u2010M","family":"Lebech","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hvidovre Hospital, University of Copenhagen Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit090"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1258\/095646206778113087"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e3282f75ea1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462413491735"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2008.00608.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-156-12-201206190-00424"},{"issue":"17","key":"e_1_2_6_8_1","first-page":"1","article-title":"1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults","volume":"41","author":"US Centers for Disease Control and Prevention","year":"1992","journal-title":"MMWR Recomm Rep"},{"issue":"4","key":"e_1_2_6_9_1","first-page":"1","article-title":"Guidelines for prevention and treatment of opportunistic infections in HIV\u2010infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America","volume":"58","author":"Kaplan JE","year":"2009","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-256"},{"key":"e_1_2_6_11_1","unstructured":"Available athttp:\/\/www.dst.dk\/da\/Statistik\/emner\/befolkning\u2010og\u2010befolkningsfremskrivning\/folketal.aspx(accessed 14 September 2012). 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