{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T10:39:04Z","timestamp":1770633544376,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T00:00:00Z","timestamp":1437523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Objectives<\/jats:title>The aim of the study was to identify differences in infant outcomes, virological efficacy, and preterm delivery (PTD<\/jats:styled-content>) outcome between women exposed to lopinavir\/ritonavir (LPV<\/jats:styled-content>\/r) and those exposed to atazanavir\/ritonavir (ATV<\/jats:styled-content>\/r).<\/jats:p><\/jats:sec>Methods<\/jats:title>A retrospective case note review was carried out. The case notes of 493 women who conceived while on LPV<\/jats:styled-content>\/r or ATV<\/jats:styled-content>\/r or initiated LPV<\/jats:styled-content>\/r or ATV<\/jats:styled-content>\/r during pregnancy and who delivered between 1 S<\/jats:styled-content>eptember 2007 and 30 A<\/jats:styled-content>ugust 2012 were reviewed. Data collected included demographics, antiretroviral use, HIV<\/jats:styled-content> markers, and pregnancy and infant outcomes. Infant outcomes, virological efficacies and PTD<\/jats:styled-content> rates for LPV<\/jats:styled-content>\/r and ATV<\/jats:styled-content>\/r were compared.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 306 women received LPV<\/jats:styled-content>\/r (82 conceiving while on the drug and 224 commencing it post\u2010conception) and 187 received ATV<\/jats:styled-content>\/r (96 conceiving while on the drug and 91 commencing it post\u2010conception). Comparing the two protease inhibitors (PIs<\/jats:styled-content>), viral suppression rates were similar and, in women starting antiretroviral therapy (ART<\/jats:styled-content>) post\u2010conception, the median times to first undetectable HIV<\/jats:styled-content> viral load were not significantly different (P<\/jats:italic>\u2009=\u20090.64). PTD<\/jats:styled-content> rates did not differ by therapy overall (ATV<\/jats:styled-content>\/r, 13%; LPV<\/jats:styled-content>\/r, 14%) or when considering the timing of first exposure (conceiving on ART<\/jats:styled-content>, P<\/jats:italic>\u2009=\u20090.81; commencing ART<\/jats:styled-content> in pregnancy, P<\/jats:italic>\u2009=\u20090.08). Poor fetal outcomes were very uncommon. There were two transmissions, giving a mother\u2010to\u2010child transmission (MTCT<\/jats:styled-content>) rate of 0.4% (95% confidence interval 0.05\u20131.5%).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Both ART<\/jats:styled-content> regimens were well tolerated and successful in preventing MTCT<\/jats:styled-content>. No significant differences in tolerability or in pregnancy or infant outcomes were observed, which supports the provision of a choice of PI<\/jats:styled-content> in pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12277","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T12:45:20Z","timestamp":1437569120000},"page":"28-35","source":"Crossref","is-referenced-by-count":15,"title":["Lopinavir and atazanavir in pregnancy: comparable infant outcomes, virological efficacies and preterm delivery rates"],"prefix":"10.1111","volume":"17","author":[{"given":"MEO","family":"Perry","sequence":"first","affiliation":[{"name":"Guy's and St Thomas' NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GP","family":"Taylor","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CA","family":"Sabin","sequence":"additional","affiliation":[{"name":"Research Department of Infection and Population Health University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Conway","sequence":"additional","affiliation":[{"name":"Guy's and St Thomas' NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Homerton University Hospital NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Dwyer","sequence":"additional","affiliation":[{"name":"Croydon University Hospital NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Croydon University Hospital NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Mulka","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"McKendry","sequence":"additional","affiliation":[{"name":"The North Middlesex University Hospital NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Williams","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Barbour","sequence":"additional","affiliation":[{"name":"St George's NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Dermont","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster Hospital NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Roedling","sequence":"additional","affiliation":[{"name":"(Mortimer Market Centre) Central and North West London NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Shah","sequence":"additional","affiliation":[{"name":"Barnet and Chase Farm Hospital NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Anderson","sequence":"additional","affiliation":[{"name":"Homerton University Hospital NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Rodgers","sequence":"additional","affiliation":[{"name":"Croydon University Hospital NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Wood","sequence":"additional","affiliation":[{"name":"The North Middlesex University Hospital NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Sarner","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Hay","sequence":"additional","affiliation":[{"name":"St George's NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster Hospital NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"deRuiter","sequence":"additional","affiliation":[{"name":"Guy's and St Thomas' NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411033311801"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-200204150-00009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/427287"},{"key":"e_1_2_6_5_1","first-page":"592","article-title":"Achievements in public health. 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