{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:44:58Z","timestamp":1790214298891,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2016,2]]},"abstract":"Objectives<\/jats:title>Pre\u2010exposure prophylaxis (PrEP<\/jats:styled-content>) has proven biological efficacy in reducing the risk of sexual acquisition of HIV<\/jats:styled-content>. Healthcare providers' (HCPs<\/jats:styled-content>) knowledge of and attitudes to PrEP<\/jats:styled-content> will be key to successful implementation. In England, PrEP<\/jats:styled-content> is only available to men who have sex with men (MSM<\/jats:styled-content>) through the open\u2010label randomized PROUD<\/jats:styled-content> pilot study of immediate or deferred use.<\/jats:p><\/jats:sec>Methods<\/jats:title>In S<\/jats:styled-content>eptember 2013, a cross\u2010sectional survey of UK HCPs<\/jats:styled-content> distributed through sexual health clinics (219) and professional societies' email lists (2599) and at a conference (80) asked about knowledge of, attitudes to and practice of PrEP<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Overall, 328 of 2898 (11%) completed the survey, of whom 160 of 328 (49%) were doctors, 51 (16%) sexual health advisers (SHAs<\/jats:styled-content>), 44 (14%) nurses and 73 (22%) unspecified. Over a quarter (83 of 311; 27%) were involved in PROUD<\/jats:styled-content>. Most respondents (260 of 326; 80%) rated their knowledge of PrEP<\/jats:styled-content> as medium or high. Over half of respondents (166 of 307; 54%) thought PrEP<\/jats:styled-content> should be available outside of a clinical trial. The main barriers to supporting PrEP<\/jats:styled-content> availability outside a clinical trial were concerns about current evidence (odds ratio [OR<\/jats:styled-content>] 0.13), lack of UK<\/jats:styled-content>\u2010specific guidance (OR<\/jats:styled-content> 0.35), concerns about adherence (OR<\/jats:styled-content> 0.38) and risk of sexual or physical coercion for patients to have condomless or higher risk sex (OR<\/jats:styled-content> 0.42 in multivariate regression). Just over half (147 of 277; 53%) had been asked about PrEP<\/jats:styled-content> by patients in the past year, including almost half of those working in a clinic not involved in the PROUD<\/jats:styled-content> study (86 of 202; 43%).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>There is support for PrEP<\/jats:styled-content> availability outside a clinical trial, but HCPs<\/jats:styled-content> have residual concerns about its effectiveness and negative consequences, and the absence of UK<\/jats:styled-content>\u2010specific implementation guidance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12285","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T13:06:44Z","timestamp":1436879204000},"page":"133-142","source":"Crossref","is-referenced-by-count":50,"title":["Healthcare providers' knowledge of, attitudes to and practice of pre\u2010exposure prophylaxis for HIV<\/scp> infection"],"prefix":"10.1111","volume":"17","author":[{"given":"M","family":"Desai","sequence":"first","affiliation":[{"name":"Clinical Trials Unit Medical Research Council London UK"},{"name":"HIV\/STI Department Public Health England London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Gafos","sequence":"additional","affiliation":[{"name":"Clinical Trials Unit Medical Research Council London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Dolling","sequence":"additional","affiliation":[{"name":"Clinical Trials Unit Medical Research Council London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"McCormack","sequence":"additional","affiliation":[{"name":"Clinical Trials Unit Medical Research Council London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Nardone","sequence":"additional","affiliation":[{"name":"HIV\/STI Department Public Health England London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"PROUD study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61235-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011205"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1108524"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110711"},{"key":"e_1_2_10_6_1","volume-title":"HIV in the United Kingdom 2014 Report: Data to End 2013","author":"Yin Z","year":"2014"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12066"},{"key":"e_1_2_10_8_1","volume-title":"HIV in the United Kingdom 2013 Report: Data to End 2012","author":"Aghaizu ABA","year":"2013"},{"key":"e_1_2_10_9_1","volume-title":"Increasing the Uptake of HIV Testing Among Men Who Have Sex with Men","author":"National Institute for Health and Clinical Excellence","year":"2011"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e3283590446"},{"key":"e_1_2_10_11_1","volume-title":"STI Data Tables for England 2013. 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