{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:10:56Z","timestamp":1760044256196},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,12,3]],"date-time":"2015-12-03T00:00:00Z","timestamp":1449100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR000124"],"award-info":[{"award-number":["UL1TR000124"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2016,8]]},"abstract":"Objectives<\/jats:title>While patients with HIV<\/jats:styled-content> infection have an elevated stroke risk, ultrasound studies of carotid artery wall thickness have reported variable results. We hypothesized that subjects with HIV<\/jats:styled-content> infection on chronic highly active antiretroviral therapy (HAART<\/jats:styled-content>) would have increased carotid artery wall thickness by magnetic resonance imaging (MRI<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>This cross\u2010sectional study compared carotid artery wall thickness between 26 individuals infected with HIV<\/jats:styled-content> on chronic HAART<\/jats:styled-content> and 20 controls, without HIV<\/jats:styled-content> infection but with similar cardiovascular risk factors, using 3.0\u2010T noncontrast MRI<\/jats:styled-content>. Inclusion criteria included male gender, age 35\u201355 years, and chronic HAART<\/jats:styled-content> (\u2265 3 years) among HIV<\/jats:styled-content>\u2010seropositive subjects; those with known cardiovascular disease or diabetes were excluded.<\/jats:p><\/jats:sec>Results<\/jats:title>Between subjects with HIV<\/jats:styled-content> infection and controls, there were no differences in mean (\u00b1SD) age (47.8 \u00b1 5.0 vs<\/jats:italic>. 47.8 \u00b1 4.7 years, respectively; P<\/jats:italic> = 0.19) or cardiovascular risk factors (P<\/jats:italic> > 0.05 for each). Mean (\u00b1SD) wall thickness was increased in those with HIV<\/jats:styled-content> infection vs<\/jats:italic>. controls for the left (0.88 \u00b1 0.08 vs<\/jats:italic>. 0.83 \u00b1 0.08 mm, respectively; P<\/jats:italic> = 0.03) and right (0.90 \u00b1 0.10 vs<\/jats:italic>. 0.85 \u00b1 0.07 mm, respectively; P<\/jats:italic> = 0.046) common carotid arteries. Among individuals with HIV<\/jats:styled-content> infection, variables associated with increased mean carotid artery wall thickness included lipoaccumulation [+0.09 mm; 95% confidence interval (CI<\/jats:styled-content>) 0.03\u20130.14 mm; P<\/jats:italic> = 0.003], Framingham risk score \u2265 5% (+0.07 mm; 95% CI<\/jats:styled-content> 0.01\u20130.12; P<\/jats:italic> = 0.02 mm), and increased duration of protease inhibitor therapy (+0.03 mm per 5 years; 95% CI<\/jats:styled-content> 0.01\u20130.06 mm; P<\/jats:italic> = 0.02).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Individuals with HIV<\/jats:styled-content> infection on chronic HAART<\/jats:styled-content> had increased carotid artery wall thickness as compared to similar controls. In subjects with HIV<\/jats:styled-content> infection, the presence of lipoaccumulation and longer duration of protease inhibitor therapy were associated with greater wall thickness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12351","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T02:24:57Z","timestamp":1449195897000},"page":"516-523","source":"Crossref","is-referenced-by-count":5,"title":["Carotid artery thickness is associated with chronic use of highly active antiretroviral therapy in patients infected with human immunodeficiency virus: A 3.0 Tesla magnetic resonance imaging study"],"prefix":"10.1111","volume":"17","author":[{"given":"TM","family":"LaBounty","sequence":"first","affiliation":[{"name":"Departments of Medicine and Radiology University of Michigan Medical Center Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WD","family":"Hardy","sequence":"additional","affiliation":[{"name":"David Geffen School of 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