{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:58:05Z","timestamp":1793177885413,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Plan Nacional I+D+i","award":["RD12\/0017\/0003"],"award-info":[{"award-number":["RD12\/0017\/0003"]}]},{"name":"Investigation Cientifica"},{"name":"Desarrollo e Innovaci\u00f3n"},{"name":"ISCIII-Subdirecci\u00f3n General de Evaluaci\u00f3n y el Fondo Europeo de Desarrollo Regional (FEDER)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Electrocautery is one of the main treatment options for high\u2010grade anal intraepithelial neoplasia (<jats:styled-content style=\"fixed-case\">HGAIN<\/jats:styled-content>). However, data regarding its efficacy are scarce. The aim of the study was to evaluate the effectiveness of electrocautery for the treatment of <jats:styled-content style=\"fixed-case\">HGAIN<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An observational study of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected men who have sex with men (<jats:styled-content style=\"fixed-case\">MSM<\/jats:styled-content>) who underwent screening for anal dysplasia was carried out. The on\u2010treatment effectiveness of electrocautery was evaluated (according to biopsy findings measured 6\u20138\u00a0weeks after treatment) in patients with <jats:styled-content style=\"fixed-case\">HGAIN<\/jats:styled-content>. A complete response was defined as resolution of anal intraepithelial neoplasia (<jats:styled-content style=\"fixed-case\">AIN<\/jats:styled-content>), a partial response as regression to low\u2010grade <jats:styled-content style=\"fixed-case\">AIN<\/jats:styled-content> and recurrence as biopsy\u2010proven <jats:styled-content style=\"fixed-case\">HGAIN<\/jats:styled-content> during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From May 2009 to November 2014, 21.9% (126 of 576) of patients screened were found to have <jats:styled-content style=\"fixed-case\">HGAIN<\/jats:styled-content>. Electrocautery effectiveness was evaluated in 83 patients. A complete response was observed in 27 patients [32.5%; 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 23.4\u201353.2%], a partial response in 28 patients (33.7%; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 24.5\u201344.4%) and persistence in 28 patients (33.7%; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 24.5\u201344.4%). The patients with the most successful results (81.8%) required two to four sessions of electrocautery. After a mean follow\u2010up of 12.1\u00a0months, 14 of 55 patients with a response (25.4%; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 15.8\u201338.3%) developed recurrent <jats:styled-content style=\"fixed-case\">HGAIN<\/jats:styled-content> within a mean time of 29.9\u00a0months (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 22\u201337.7\u00a0months). No patient progressed to invasive cancer during the study or developed serious adverse events after treatment. No factors associated with poor response or recurrences were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although electrocautery is the standard treatment for anal dysplasia, almost 50% of patients with <jats:styled-content style=\"fixed-case\">HGAIN<\/jats:styled-content> in our study did not respond or relapsed. New treatment strategies are necessary to optimize the management of anal dysplasia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12352","type":"journal-article","created":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T07:44:56Z","timestamp":1450683896000},"page":"524-531","source":"Crossref","is-referenced-by-count":46,"title":["The effectiveness of electrocautery ablation for the treatment of high\u2010grade anal intraepithelial neoplasia in <scp>HIV<\/scp>\u2010infected men who have sex with men"],"prefix":"10.1111","volume":"17","author":[{"given":"J","family":"Burgos","sequence":"first","affiliation":[{"name":"Infectious Diseases Department Vall d'Hebron University Hospital Vall d'Hebron Research Institute (VHIR) Autonomous University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Curran","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Vall d'Hebron University Hospital Vall d'Hebron Research Institute (VHIR) Autonomous University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Landolfi","sequence":"additional","affiliation":[{"name":"Anatomical Pathology Department Vall d'Hebron University Hospital Vall d'Hebron Research Institute (VHIR) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Navarro","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Vall d'Hebron University Hospital Vall d'Hebron Research Institute (VHIR) Autonomous University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Tallada","sequence":"additional","affiliation":[{"name":"Anatomical Pathology Department Vall d'Hebron University Hospital Vall d'Hebron Research Institute (VHIR) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Guelar","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Mar University Hospital Autonomous University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Crespo","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Vall d'Hebron University Hospital Vall d'Hebron Research Institute (VHIR) Autonomous University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Oca\u00f1a","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Vall d'Hebron University Hospital Vall d'Hebron Research Institute (VHIR) Autonomous University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Ribera","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Vall d'Hebron University Hospital Vall d'Hebron Research Institute (VHIR) Autonomous University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Falc\u00f3","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Vall d'Hebron University Hospital Vall d'Hebron Research Institute (VHIR) Autonomous University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir1012"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr076"},{"key":"e_1_2_6_4_1","first-page":"122","article-title":"Human papillomavirus, anal cancer, and screening considerations among HIV\u2010infected individuals","volume":"15","author":"Cachay ER","year":"2013","journal-title":"AIDS Rev"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70080-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000160"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.293.6548.659"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S38217"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2013.04.011"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70067-6"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6219-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3182437469"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000603"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02051199"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-2042-8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-0889-0"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-006-0874-x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181582d93"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir1036"},{"key":"e_1_2_6_20_1","first-page":"474","article-title":"Efficacy of trichloroacetic acid in the treatment of anal intraepithelial neoplasia in HIV\u2010positive and HIV\u2010negative men who have sex with men","volume":"52","author":"Singh JC","year":"2009","journal-title":"J Acquir Immune Defic Syndr"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32833d466c"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e318227833e"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283633111"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104116"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhiv.12352","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.12352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T22:39:58Z","timestamp":1695508798000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.12352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,21]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/hiv.12352"],"URL":"https:\/\/doi.org\/10.1111\/hiv.12352","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,21]]}}}