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We sought to examine the impact of amphotericin\u2010related anaemia on survival.<\/jats:p><\/jats:sec>Methods<\/jats:title>We used data from Ugandan and South African trial participants to characterize the variation of haemoglobin concentrations from diagnosis to 12 weeks post\u2010diagnosis. Anaemia severity was classified based on the haemoglobin concentration at cryptococcal meningitis diagnosis, and nadir haemoglobin values during amphotericin induction. Cox proportional hazard models were used to estimate 2\u2010 and 10\u2010week mortality risk. We also estimated 10\u2010week mortality risk among participants with nadir haemoglobin < 8.5 g\/dL<\/jats:styled-content> during amphotericin induction and who survived \u2265 2 weeks post\u2010enrolment.<\/jats:p><\/jats:sec>Results<\/jats:title>The median haemoglobin concentration at meningitis diagnosis was 11.5 g\/dL<\/jats:styled-content> [interquartile range (IQR<\/jats:styled-content>) 9.7\u201313 g\/dL<\/jats:styled-content>; n<\/jats:italic> = 311] with a mean decline of 4.2 g\/dL<\/jats:styled-content> [95% confidence interval (CI<\/jats:styled-content>) \u22124.6 to \u22123.8; P<\/jats:italic> < 0.001; n<\/jats:italic> = 148] from diagnosis to nadir value among participants with baseline haemoglobin \u2265 8.5 g\/dL<\/jats:styled-content>. The median haemoglobin concentration was 8.1 g\/dL<\/jats:styled-content> (IQR<\/jats:styled-content> 6.5\u20139.5 g\/dL<\/jats:styled-content>) at 2 weeks, increasing to 9.4 g\/dL<\/jats:styled-content> (IQR<\/jats:styled-content> 8.2\u201310.9 g\/dL<\/jats:styled-content>) by 4 weeks and continuing to increase to 12 weeks. Among participants with haemoglobin < 8.5 g\/dL<\/jats:styled-content> at diagnosis, mortality risk was elevated at 2 weeks [hazard ratio (HR<\/jats:styled-content>) 2.7; 95% CI<\/jats:styled-content> 1.5\u20134.9; P<\/jats:italic> < 0.01] and 10 weeks (HR<\/jats:styled-content> 1.8; 95% CI<\/jats:styled-content> 1.1\u20132.2; P<\/jats:italic> = 0.03), relative to those with haemoglobin \u2265 8.5 g\/dL<\/jats:styled-content>. New\u2010onset anaemia occurring with amphotericin therapy did not have a statistically significant association with 10\u2010week mortality (HR<\/jats:styled-content> 2.0; 95% CI 0.5\u20139.1; P<\/jats:italic> = 0.4).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Amphotericin induced significant haemoglobin declines, which were mostly transient and did not impact 10\u2010week mortality. Individuals with moderate to life\u2010threatening anaemia at baseline had a higher mortality risk at 2 and 10 weeks post\u2010enrolment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12387","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T10:17:57Z","timestamp":1462011477000},"page":"13-20","source":"Crossref","is-referenced-by-count":28,"title":["Prognostic implications of baseline anaemia and changes in haemoglobin concentrations with amphotericin B therapy for cryptococcal meningitis"],"prefix":"10.1111","volume":"18","author":[{"given":"L","family":"Tugume","sequence":"first","affiliation":[{"name":"Infectious Disease Institute Makerere University Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1655-6006","authenticated-orcid":false,"given":"BM","family":"Morawski","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and International Medicine Department of 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