{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:28:41Z","timestamp":1790252921394,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012352","name":"University of Milan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012352","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Clinical trials of all\u2010oral direct\u2010acting antivirals (<jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>s) for chronic hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) infection reported high response rates in <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> coinfection, similar to those obtained in <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> monoinfection. We evaluated the safety and efficacy of these regimens in a clinical practice setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective observational study, all the <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010monoinfected and <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010coinfected patients undergoing <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> treatment with all\u2010oral <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content> regimens in a routine clinical setting from December 2014 to December 2015 were included in the analysis. Sustained virological response 12 weeks after the end of therapy (<jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>12) and reported adverse events (<jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s) were evaluated. Resistance\u2010associated variants (<jats:styled-content style=\"fixed-case\">RAV<\/jats:styled-content>s) were analysed in a subgroup of patients at baseline and at the time of viral rebound in those with virological failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010hundred and nine patients (51 <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010infected and 58 <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010coinfected) were enrolled in the study. Sixty per cent had cirrhosis and 52% were pegylated interferon and ribavirin (peg<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">RBV<\/jats:styled-content>)\u2010experienced. Thirty\u2010six per cent received ombitasvir + paritaprevir\/ritonavir + dasabuvir, 25% sofosbuvir + daclatasvir, 16% sofosbuvir + simeprevir, 17% sofosbuvir + ribavirin and 6% sofosbuvir + ledipasvir; ribavirin was used in 57% of subjects. The <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>12 rate was 91% and 96% in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected and uninfected patients, respectively (<jats:italic>P<\/jats:italic> = 0.44). The 4\u2010week <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> viral decline was similar in the two groups. <jats:styled-content style=\"fixed-case\">RAV<\/jats:styled-content>s were found at baseline in 23 of 49 patients and did not affect <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>12. No predictors of <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>12 were identified in our cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment with all\u2010oral <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content> combinations of patients infected with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> and with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> under real\u2010life conditions led to high and similar rates of <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>12. Moreover, the historical factors associated with a sustained virological response to peg<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">RBV<\/jats:styled-content> were not predictive of the response to all\u2010oral <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12429","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T16:36:40Z","timestamp":1470155800000},"page":"284-291","source":"Crossref","is-referenced-by-count":67,"title":["Direct\u2010acting antivirals in hepatitis C virus (<scp>HCV<\/scp>)\u2010infected and <scp>HCV<\/scp>\/<scp>HIV<\/scp>\u2010coinfected patients: real\u2010life safety and efficacy"],"prefix":"10.1111","volume":"18","author":[{"given":"L","family":"Milazzo","sequence":"first","affiliation":[{"name":"Department of Biomedical and Clinical Sciences L. Sacco University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences L. Sacco University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Calvi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences L. Sacco University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Ronzi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences L. Sacco University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Micheli","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Virology and Diagnosis of Bioemergency L. Sacco University Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Binda","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences L. Sacco University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AL","family":"Ridolfo","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences L. Sacco University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Gervasoni","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences L. Sacco University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Galli","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences L. 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