{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T21:56:58Z","timestamp":1784325418505,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T00:00:00Z","timestamp":1479254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002141","name":"Public Health England","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002141","name":"Public Health England","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000276","name":"Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the study was to compare maternal characteristics and pregnancy outcomes in women aged &lt; 40 years and \u2265 40 years in a large unselected population of<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive women delivering in the<jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>and Ireland between 2000 and 2014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Comprehensive population\u2010based surveillance data on all<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive pregnant women and their children seen for care in the<jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>and Ireland are collected through the National Study of<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>in Pregnancy and Childhood. All singleton and multiple pregnancies reported by the end of June 2015 resulting in live birth or stillbirth to women diagnosed with<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>infection before delivery and delivering in 2000\u22122014 were included. Logistic regression models were fitted in analyses examining the association between older maternal age and specific outcomes (preterm delivery and stillbirth).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 15 501 pregnancies in<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive women, the proportion in older women (\u2265 40 years) increased from 2.1% (73 of 3419) in 2000\u22122004 to 8.9% (510 of 5748) in 2010\u22122014 (<jats:italic>P<\/jats:italic>&lt; 0.001). Compared with pregnancies in younger women, those in older women were more likely to result in multiple birth (3.0<jats:italic>vs<\/jats:italic>. 1.9% in younger women;<jats:italic>P<\/jats:italic>= 0.03), stillbirth (adjusted odds ratio 2.39;<jats:italic>P<\/jats:italic>= 0.004) or an infant with a chromosomal abnormality (1.6<jats:italic>vs<\/jats:italic>. 0.2%, respectively;<jats:italic>P<\/jats:italic>&lt; 0.001). However, there was no increased risk of preterm delivery, low birth weight or mother\u2010to\u2010child<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>transmission among older mothers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There has been a significant increase over time in the proportion of deliveries to women living with<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>aged \u2265 40 years, which has implications for pregnancy management, given their increased risk of multiple births, stillbirth and chromosomal anomalies, as also apparent in the general population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12469","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T20:00:40Z","timestamp":1479326440000},"page":"507-512","source":"Crossref","is-referenced-by-count":6,"title":["Pregnancies in older women living with<scp>HIV<\/scp>in the<scp>UK<\/scp>and Ireland"],"prefix":"10.1111","volume":"18","author":[{"given":"CL","family":"Townsend","sequence":"first","affiliation":[{"name":"Population, Policy and Practice Programme UCL Institute of Child Health University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"de Ruiter","sequence":"additional","affiliation":[{"name":"Guys &amp; St Thomas' NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Peters","sequence":"additional","affiliation":[{"name":"Population, Policy and Practice Programme UCL Institute of Child Health University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Nelson\u2010Piercy","sequence":"additional","affiliation":[{"name":"Guys &amp; St Thomas' NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Tookey","sequence":"additional","affiliation":[{"name":"Population, Policy and Practice Programme UCL Institute of Child Health University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Thorne","sequence":"additional","affiliation":[{"name":"Population, Policy and Practice Programme UCL Institute of Child Health University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31823dbeac"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283565df1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081355"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000212"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e3283636ccb"},{"key":"e_1_2_7_7_1","unstructured":"Office for National Statistics.Characteristics of Mother 1 England and Wales 2013.2014. Available athttp:\/\/www.ons.gov.uk\/ons\/rel\/vsob1\/characteristics-of-Mother-1-england-and-wales\/2013\/stb-characteristics-of-mother-1-2013.html(accessed 27 June 2016)."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01706.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62233-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del522"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2014.885837"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1310\/hct1403-110"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2010.0365"},{"key":"e_1_2_7_14_1","volume-title":"International Statistical Classification of Diseases and Related Health Problems","author":"World Health Organization","year":"1992"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X0200200101"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/5.2.179"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1983.03330390038028"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056583"},{"key":"e_1_2_7_19_1","unstructured":"Office for National Statistics.Statistical Bulletin: Birth characteristics in England and Wales: 2014. Available athttp:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/birthsdeathsandmarriages\/livebirths\/bulletins\/birthcharacteristicsinenglandandwales\/2015-10-08(accessed 27 June 2016)"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12659"},{"key":"e_1_2_7_21_1","first-page":"22","article-title":"Birthweight and gestational age by ethnic group, England and Wales 2005: introducing new data on births","volume":"39","author":"Moser K","year":"2008","journal-title":"Health Stat Q"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2010.482126"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1093\/cid\/civ578","article-title":"No perinatal HIV\u20101 transmission from women with effective antiretroviral therapy starting before conception","volume":"61","author":"Mandelbrot L","year":"2015","journal-title":"Clin Infect Dis"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12142"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhiv.12469","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhiv.12469","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.12469","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T16:59:11Z","timestamp":1749747551000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.12469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,16]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/hiv.12469"],"URL":"https:\/\/doi.org\/10.1111\/hiv.12469","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,16]]}}}