{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:18:09Z","timestamp":1791613089125,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T00:00:00Z","timestamp":1489363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1\u2010TR001079"],"award-info":[{"award-number":["UL1\u2010TR001079"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2017,9]]},"abstract":"Objectives<\/jats:title>HIV<\/jats:styled-content>\u2010associated neurocognitive disorders are highly prevalent, and physical activity (PA<\/jats:styled-content>) is a modifiable behaviour that may affect neurocognitive function. Our objective was to determine the association between PA and neurocognitive function and the effect of HIV on this association.<\/jats:p><\/jats:sec>Methods<\/jats:title>PA<\/jats:styled-content> was assessed in the Multicenter AIDS<\/jats:styled-content> Cohort Study with the International Physical Activity Questionnaire. A neuropsychological test battery assessed global impairment and domain\u2010specific impairment (executive function, speed of processing, working memory, learning, memory, and motor function) every 2 years. Semiannually, the Symbol Digit Modalities Test and Trail Making Test Parts A and B were performed. Adjusted logistic regression models were used to assess the PA<\/jats:styled-content>\u2013neurocognitive function association. Using longitudinal data, we also assessed the PA<\/jats:styled-content> category\u2013decline of neurocognitive function association with multivariate simple regression.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 601 men, 44% were HIV<\/jats:styled-content>\u2010infected. Low, moderate, and high PA<\/jats:styled-content> was reported in 27%, 25%, and 48% of the HIV<\/jats:styled-content>\u2010infected men vs. 19%, 32% and 49% of the HIV<\/jats:styled-content>\u2010uninfected men, respectively. High PA<\/jats:styled-content> was associated with lower odds of impairment of learning, memory, and motor function [odds ratio (OR<\/jats:styled-content>) ranging from 0.52 to 0.57; P<\/jats:italic> < 0.05 for all]. The high PA<\/jats:styled-content>\u2013global impairment association OR<\/jats:styled-content> was 0.63 [95% confidence interval (CI<\/jats:styled-content>) 0.39, 1.02]. Among HIV<\/jats:styled-content>\u2010infected men only, across multiple domains, the high PA<\/jats:styled-content>\u2013impairment association was even more pronounced (OR<\/jats:styled-content> from 0.27 to 0.49). Baseline high\/moderate PA<\/jats:styled-content> was not associated with decline of any domain score over time. HIV<\/jats:styled-content> infection was marginally associated with a higher speed of decline in motor function.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>A protective effect of high PA<\/jats:styled-content> on impairment in neurocognitive domains was observed cross\u2010sectionally. Longitudinal PA<\/jats:styled-content> measurements are needed to elucidate the PA<\/jats:styled-content>\u2013neurocognitive function relationship over time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12490","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T16:44:34Z","timestamp":1489509874000},"page":"555-563","source":"Crossref","is-referenced-by-count":31,"title":["The association between physical activity and cognition in men with and without HIV<\/scp> infection"],"prefix":"10.1111","volume":"18","author":[{"given":"AK","family":"Monroe","sequence":"first","affiliation":[{"name":"Department of Medicine Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD 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