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Direct\u2010acting antiviral (DAA<\/jats:styled-content>) therapies offer an opportunity to expand treatment access among this population. The aim of this study was to explore willingness to use DAA<\/jats:styled-content>\u2010based regimens among HIV<\/jats:styled-content>\/HCV<\/jats:styled-content>\u2010coinfected PWUD<\/jats:styled-content> in Vancouver, Canada.<\/jats:p><\/jats:sec>Methods<\/jats:title>Data were drawn from the AIDS<\/jats:styled-content> Care Cohort to evaluate Exposure to Survival Services (ACCESS<\/jats:styled-content>), a prospective cohort of HIV<\/jats:styled-content>\u2010positive PWUD<\/jats:styled-content>. Using logistic regression analyses, we investigated factors associated with willingness to use DAA<\/jats:styled-content>\u2010based regimens among HIV<\/jats:styled-content>\/HCV<\/jats:styled-content>\u2010coinfected participants.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 418 HIV<\/jats:styled-content>\/HCV<\/jats:styled-content>\u2010coinfected PWUD<\/jats:styled-content> surveyed between June 2014 and May 2015, 295 (71%) were willing to use DAA<\/jats:styled-content>\u2010based regimens. In multivariable analysis, participants enrolled in methadone maintenance therapy [adjusted odds ratio (AOR<\/jats:styled-content>) 1.61; 95% confidence interval (CI<\/jats:styled-content>) 1.04\u20132.51], those with a recent assessment by an HCV<\/jats:styled-content> specialist (AOR<\/jats:styled-content> 2.02; 95% CI<\/jats:styled-content> 1.28\u20133.19) and those who perceived that HCV<\/jats:styled-content> infection was affecting their health (AOR<\/jats:styled-content> 2.49; 95% CI<\/jats:styled-content> 1.41\u20134.37) were more likely to be willing to use DAA<\/jats:styled-content>\u2010based regimens.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Overall, this study found a high prevalence of willingness to use DAA<\/jats:styled-content>\u2010based regimens among HIV<\/jats:styled-content>\/HCV<\/jats:styled-content>\u2010coinfected PWUD<\/jats:styled-content> in Vancouver. Importantly, enrolment in methadone maintenance therapy was positively associated with willingness, suggesting that integrated models of HIV<\/jats:styled-content>, HCV<\/jats:styled-content> and addiction care should be explored as a way to address HCV<\/jats:styled-content>\u2010related morbidity and mortality among HIV<\/jats:styled-content>\/HCV<\/jats:styled-content>\u2010coinfected PWUD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12501","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T16:49:58Z","timestamp":1489510198000},"page":"647-654","source":"Crossref","is-referenced-by-count":12,"title":["High prevalence of willingness to use direct\u2010acting antiviral\u2010based regimens for hepatitis C virus (HCV<\/scp>) infection among HIV<\/scp>\/HCV<\/scp> coinfected people who use drugs"],"prefix":"10.1111","volume":"18","author":[{"given":"ME","family":"Soc\u00edas","sequence":"first","affiliation":[{"name":"British Columbia Centre for Excellence in HIV\/AIDS St. Paul's Hospital Vancouver BC Canada"},{"name":"Department of Medicine University of British Columbia St. Paul's Hospital Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Ti","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Excellence in HIV\/AIDS St. Paul's Hospital Vancouver BC Canada"},{"name":"Department of Medicine University of British Columbia St. Paul's Hospital Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Dong","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Excellence in HIV\/AIDS St. Paul's Hospital Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Shoveller","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Excellence in HIV\/AIDS St. Paul's Hospital Vancouver BC Canada"},{"name":"School of Population and Public Health University of British Columbia Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kerr","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Excellence in HIV\/AIDS St. Paul's Hospital Vancouver BC Canada"},{"name":"Department of Medicine University of British Columbia St. Paul's Hospital Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Montaner","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Excellence in HIV\/AIDS St. Paul's Hospital Vancouver BC Canada"},{"name":"Department of Medicine University of British Columbia St. Paul's Hospital Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u2010J","family":"Milloy","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Excellence in HIV\/AIDS St. Paul's Hospital Vancouver BC Canada"},{"name":"Department of Medicine University of British Columbia St. Paul's Hospital Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00485-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit326"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis928"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit103"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000183"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ396"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2015.07.005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474124.2016.1145545"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27310"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10900-007-9083-3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12129"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12008"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit306"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis1007"},{"key":"e_1_2_7_16_1","first-page":"124","volume-title":"Guidelines for the Screening, Care and Treatment of Persons with Hepatitis C Infection","author":"World Health Organization","year":"2014"},{"key":"e_1_2_7_17_1","unstructured":"AASLD\/IDSA.Recommendations for testing managing and treating hepatitis C. 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