{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:48:04Z","timestamp":1778694484401,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T00:00:00Z","timestamp":1503446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Canadian Institutes of Health Research (CIHR) Canadian HIV Trials Network","award":["CTN-216"],"award-info":[{"award-number":["CTN-216"]}]},{"name":"AIDS\/Infectious Diseases Network of Fonds de Recherche Qu\u00e9bec \u2212 Sant\u00e9 (FRQS)"},{"name":"Roche Diagnostics"},{"name":"Merck Sharp and Dome"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Men who have sex with men (<jats:styled-content style=\"fixed-case\">MSM<\/jats:styled-content>) living with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> are at high risk for anal high\u2010grade squamous intraepithelial lesions (<jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>s) and cancer. The best management of anal <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content> remains unclear. Our objective was to assess whether argon plasma coagulation (<jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content>) could be safe, well tolerated and efficient to treat anal <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">MSM<\/jats:styled-content> living with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective phase <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, open\u2010label, pilot study was conducted to evaluate <jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content> to treat anal <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>s in 20 <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive <jats:styled-content style=\"fixed-case\">MSM<\/jats:styled-content>. Participants were followed for 2 years after their first treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty men with persistent <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>s completed the 2\u2010year study. Their baseline median <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 count was 490 cells\/\u03bcL and 85% had undetectable <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> viral loads. Overall, 65% (13\/20) of participants were clear of <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>s at their 24\u2010month visit. The initial response rates after the first, second and third <jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content> treatments were 45%, 44% and 67%, respectively, but recurrences were common. The main side effect was pain during and within 1 week after the treatments. There were no long\u2010term side effects, nor serious adverse events related to the procedure. Cost is a drawback.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content> can be used to treat anal <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010seropositive <jats:styled-content style=\"fixed-case\">MSM<\/jats:styled-content>, and requires repeated treatment because of a high recurrence rate. As successful treatment of human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) infection or eradication of the anal transitional zone remains impossible, <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content> treatment is challenging and requires long\u2010term follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12544","type":"journal-article","created":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T06:32:35Z","timestamp":1503469955000},"page":"81-89","source":"Crossref","is-referenced-by-count":11,"title":["Argon plasma coagulation treatment of anal high\u2010grade squamous intraepithelial lesions in men who have sex with men living with <scp>HIV<\/scp>: results of a 2\u2010year prospective pilot study"],"prefix":"10.1111","volume":"19","author":[{"given":"A","family":"de Pokomandy","sequence":"first","affiliation":[{"name":"Family Medicine Department McGill University Montreal QC Canada"},{"name":"Chronic Viral 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