{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:40:48Z","timestamp":1792640448829,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T00:00:00Z","timestamp":1516838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772170"],"award-info":[{"award-number":["81772170"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["20120071120050"],"award-info":[{"award-number":["20120071120050"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2018,5]]},"abstract":"\n Objectives<\/jats:title>\n \n Kaposi's sarcoma (\n KS<\/jats:styled-content>\n ) is a multicentric angioproliferative cancer of endothelial origin typically occurring in the context of immunosuppression or immunodeficiency. Consequently,\n KS<\/jats:styled-content>\n is one of the most common cancers in\n HIV<\/jats:styled-content>\n \u2010infected individuals and frequently occurs among transplant recipients. Nevertheless, its incidence in different populations is not well understood.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We searched online databases for publications on\n KS<\/jats:styled-content>\n incidence. A random\u2010effect meta\u2010analysis was performed to combine the\n KS<\/jats:styled-content>\n incidences and incidence rate ratios (\n IRR<\/jats:styled-content>\n s) for associated risk factors.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Seventy\u2010six eligible studies representing 71 time periods were included. For\n HIV<\/jats:styled-content>\n \u2010infected people, the overall\n KS<\/jats:styled-content>\n incidence was 481.54 per 100\u00a0000 person\u2010years with a 95% confidential interval (\n CI<\/jats:styled-content>\n ) of 342.36\u2013677.32 per 100\u00a0000 person\u2010years.\n HIV<\/jats:styled-content>\n \u2010infected men who have sex with men (\n MSM<\/jats:styled-content>\n ) had the highest incidence of\n KS<\/jats:styled-content>\n (1397.11 per 100\u00a0000 person\u2010years; 95%\n CI<\/jats:styled-content>\n 870.55\u20132242.18 per 100\u00a0000 person\u2010years). The incidence of\n KS<\/jats:styled-content>\n was significantly lower in female than in male individuals (\n IRR<\/jats:styled-content>\n 3.09; 95%\n CI<\/jats:styled-content>\n 1.70\u20135.62). People receiving highly active antiretroviral therapy (\n HAART<\/jats:styled-content>\n ) had a lower incidence compared with people who had never received\n HAART<\/jats:styled-content>\n (\n IRR<\/jats:styled-content>\n 6.57; 95%\n CI<\/jats:styled-content>\n 1.91\u201324.69). The incidence of\n KS<\/jats:styled-content>\n was 68.59 (95%\n CI<\/jats:styled-content>\n 31.39\u2013149.86) per 100\u00a0000 person\u2010years in transplant recipients, 52.94 (95%\n CI<\/jats:styled-content>\n 39.90\u201370.20) per 100\u00a0000 person\u2010years in children with\n HIV<\/jats:styled-content>\n infection, and 1.53 (95%\n CI<\/jats:styled-content>\n 0.33\u20137.08) per 100\u00a0000 person\u2010years in the general population.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Globally, a relatively high incidence of\n KS<\/jats:styled-content>\n was found among\n HIV<\/jats:styled-content>\n \u2010seropositive people and, in particular, in\n HIV<\/jats:styled-content>\n \u2010infected\n MSM<\/jats:styled-content>\n . The introduction of\n HAART<\/jats:styled-content>\n has largely prevented the development of\n KS<\/jats:styled-content>\n , but it has not entirely removed the challenge of\n KS<\/jats:styled-content>\n . In Africa, in particular,\n KS<\/jats:styled-content>\n imposes a very heavy disease burden, which can mainly be attributed to the high prevalence of\n KS<\/jats:styled-content>\n \u2010associated herpesvirus and poor access to\n HAART<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hiv.12584","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T00:06:46Z","timestamp":1516838806000},"page":"355-364","source":"Crossref","is-referenced-by-count":71,"title":["The world\u2010wide incidence of Kaposi's sarcoma in the\n HIV<\/scp>\n \/\n AIDS<\/scp>\n era"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-6894","authenticated-orcid":false,"given":"Z","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Epidemiology School of Public Health Fudan University Shanghai China"},{"name":"Key Laboratory of Public Health Safety (Fudan University) Ministry of Education Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health Fudan University Shanghai China"},{"name":"Key Laboratory of Public Health Safety (Fudan University) Ministry of Education Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health Fudan University Shanghai China"},{"name":"Key Laboratory of Public Health Safety (Fudan University) Ministry of Education Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Minhas","sequence":"additional","affiliation":[{"name":"Nebraska Center of Virology and the School of Biological Sciences University of Nebraska\u2010Lincoln Lincoln NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Wood","sequence":"additional","affiliation":[{"name":"Nebraska Center of Virology and the School of Biological Sciences University of Nebraska\u2010Lincoln Lincoln NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health Fudan University Shanghai China"},{"name":"Key Laboratory of Public Health Safety (Fudan University) Ministry of Education Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2888"},{"key":"e_1_2_7_3_1","first-page":"418","volume-title":"Sexually Transmitted Infection","author":"Rebecca 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