{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:50:06Z","timestamp":1770825006233,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T00:00:00Z","timestamp":1518566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000380","name":"Guy's and St Thomas's Charity","doi-asserted-by":"crossref","award":["R090767, R041051"],"award-info":[{"award-number":["R090767, R041051"]}],"id":[{"id":"10.13039\/501100000380","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the study was to investigate the hypothesis of accelerated cognitive ageing in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive individuals using longitudinal assessment of cognitive performance and quantitative magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed a broad cognitive battery and quantitative <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> metrics [voxel\u2010based morphometry (<jats:styled-content style=\"fixed-case\">VBM<\/jats:styled-content>) and diffusion tensor imaging (<jats:styled-content style=\"fixed-case\">DTI<\/jats:styled-content>)] in asymptomatic <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive men who have sex with men (15 aged 20\u201340 years and 15 aged \u2265 50 years), and <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010seronegative matched controls (nine aged 20\u201340 years and 16 aged \u2265 50 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Being <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> positive was associated with greater decreases in executive function and global cognition. Additionally, using <jats:styled-content style=\"fixed-case\">DTI<\/jats:styled-content>, we found that the <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive group had a greater increase in mean diffusivity, but we did not find group differences in volume change using <jats:styled-content style=\"fixed-case\">VBM<\/jats:styled-content>. With respect to the <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> status by age group interaction, this was statistically significant for change in global cognition, with older <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive individuals showing greater global cognitive decline, but there were no significant interaction effects on other measures. Lastly, change in cognitive performance was correlated with change in the <jats:styled-content style=\"fixed-case\">DTI<\/jats:styled-content> measures, and this effect was stronger for the <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the present study, we found some evidence for accelerated ageing in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive individuals, with a statistically significant <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> status by age group interaction in global cognition, although this interaction could not be explained by the imaging findings. Moreover, we also found that change in cognitive performance was correlated with change in the <jats:styled-content style=\"fixed-case\">DTI<\/jats:styled-content> measures, and this effect was stronger for the <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive participants. This will need replication in larger studies using a similarly lengthy follow\u2010up period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12598","type":"journal-article","created":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T06:36:54Z","timestamp":1518590214000},"page":"376-385","source":"Crossref","is-referenced-by-count":22,"title":["<scp>HIV<\/scp>: ageing, cognition and neuroimaging at 4\u2010year follow\u2010up"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0054-6591","authenticated-orcid":false,"given":"BI","family":"Haynes","sequence":"first","affiliation":[{"name":"King's College London (Institute of Psychiatry, Psychology and Neuroscience) London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Pitkanen","sequence":"additional","affiliation":[{"name":"King's College London (Institute of Psychiatry, Psychology and Neuroscience) London UK"},{"name":"South London and Maudsley NHS Trust based at St Thomas' Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Kulasegaram","sequence":"additional","affiliation":[{"name":"Guy's and St Thomas' NHS Trust St Thomas' Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SJ","family":"Casey","sequence":"additional","affiliation":[{"name":"King's College London (Institute of Psychiatry, Psychology and Neuroscience) London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Schutte","sequence":"additional","affiliation":[{"name":"King's College London (Institute of Psychiatry, Psychology and Neuroscience) London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Towgood","sequence":"additional","affiliation":[{"name":"King's College London (Institute of Psychiatry, Psychology and Neuroscience) London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Peters","sequence":"additional","affiliation":[{"name":"King's College London (Institute of Psychiatry, Psychology and Neuroscience) London UK"},{"name":"South London and Maudsley NHS Trust based at St Thomas' Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GJ","family":"Barker","sequence":"additional","affiliation":[{"name":"King's College London (Institute of Psychiatry, Psychology and Neuroscience) London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MD","family":"Kopelman","sequence":"additional","affiliation":[{"name":"King's College London (Institute of Psychiatry, Psychology and Neuroscience) London UK"},{"name":"South London and Maudsley NHS Trust based at St Thomas' Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir387"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61113-7"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283437f9a"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318200d727"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/13550280290049615"},{"key":"e_1_2_6_7_1","unstructured":"Public Health England.HIV in the United Kingdom: 2014 Report 2014[Sept 2016]. 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