{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T16:51:25Z","timestamp":1789923085770,"version":"4.0.1"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2018,5]]},"abstract":"\n Background<\/jats:title>\n \n The European\n AIDS<\/jats:styled-content>\n Clinical Society (\n EACS<\/jats:styled-content>\n ) Guidelines have since 2005 provided multidisciplinary recommendations for the care of\n HIV<\/jats:styled-content>\n \u2010positive persons in geographically diverse areas.\n <\/jats:p>\n <\/jats:sec>\n \n Guideline highlights<\/jats:title>\n \n Major revisions have been made in all sections of the 2017 Guidelines: antiretroviral treatment (\n ART<\/jats:styled-content>\n ), comorbidities, coinfections and opportunistic diseases. Newly added are also a summary of the main changes made, and direct video links to the\n EACS<\/jats:styled-content>\n online course on\n HIV<\/jats:styled-content>\n Management. Recommendations on the clinical situations in which tenofovir alafenamide may be considered over tenofovir disoproxil fumarate are provided, and recommendations on which antiretrovirals can be used safely during pregnancy have been revised. Renal and bone toxicity and hepatitis C virus (\n HCV<\/jats:styled-content>\n ) treatment have been added as potential reasons for\n ART<\/jats:styled-content>\n switches in fully virologically suppressed individuals, and dolutegravir\/rilpivirine has been included as a treatment option. In contrast, dolutegravir monotherapy is not recommended. New recommendations on non\u2010alcoholic fatty liver disease, chronic lung disease, solid organ transplantation, and prescribing in elderly are included, and human papilloma virus (\n HPV<\/jats:styled-content>\n ) vaccination recommendations have been expanded. All drug\u2013drug interaction tables have been updated and new tables are included. Treatment options for direct\u2010acting antivirals (\n DAA<\/jats:styled-content>\n s) have been updated and include the latest combinations of sofosbuvir\/velpatasvir\/voxilaprevir and glecaprevir\/pibrentasvir. Recommendations on management of\n DAA<\/jats:styled-content>\n failure and acute\n HCV<\/jats:styled-content>\n infection have been expanded. For treatment of tuberculosis (\n TB<\/jats:styled-content>\n ), it is underlined that intermittent treatment is contraindicated, and for resistant\n TB<\/jats:styled-content>\n new data suggest that using a three\u2010drug combination may be as effective as a five\u2010drug regimen, and may reduce treatment duration from 18\u201024 to 6\u201010\u00a0months.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Version 9.0 of the\n EACS<\/jats:styled-content>\n Guidelines provides a holistic approach to\n HIV<\/jats:styled-content>\n care and is translated into the six most commonly spoken languages.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hiv.12600","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T04:46:36Z","timestamp":1519879596000},"page":"309-315","source":"Crossref","is-referenced-by-count":83,"title":["Highlights of the 2017 European\n AIDS<\/scp>\n Clinical Society (EACS) Guidelines for the treatment of adult\n HIV<\/scp>\n \u2010positive persons version 9.0"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6436-6461","authenticated-orcid":false,"given":"L","family":"Ryom","sequence":"first","affiliation":[{"name":"CHIP Department of Infectious Diseases Section\u00a02100, Finsencentret Rigshospitalet University Hospital of Copenhagen University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Boesecke","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bracchi","sequence":"additional","affiliation":[{"name":"HIV\/GUM Department Chelsea and Westminster NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Ambrosioni","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service Hospital Clinic\u2010IDIBAPS University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Pozniak","sequence":"additional","affiliation":[{"name":"Chelsea and Westminister Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Arribas","sequence":"additional","affiliation":[{"name":"HIV Unit, Hospital La Paz Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Behrens","sequence":"additional","affiliation":[{"name":"Clinic for Immunology and Rheumatology Medical School Hannover Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PGM","family":"Mallon","sequence":"additional","affiliation":[{"name":"HIV Molecular Research Group School of Medicine University College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Puoti","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hospital Niguerda Ca\u2019 Granda Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Rauch","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Inselspital Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JM","family":"Miro","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service Hospital Clinic\u2010IDIBAPS University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Kirk","sequence":"additional","affiliation":[{"name":"CHIP Department of Infectious Diseases Section\u00a02100, Finsencentret Rigshospitalet University Hospital of Copenhagen University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Marzolini","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology University Hospital Basel and University of Basel Basel Switzerland"},{"name":"Department of Molecular and Clinical Pharmacology Institute of Translational Medicine University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JD","family":"Lundgren","sequence":"additional","affiliation":[{"name":"CHIP Department of Infectious Diseases Section\u00a02100, Finsencentret Rigshospitalet University Hospital of Copenhagen University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Battegay","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology University Hospital Basel and University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the EACS Governing Board","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"European AIDS Clinical Society Guidelines v9.0 October 2017."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12322"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13310"},{"key":"e_1_2_10_5_1","unstructured":"BestB StekA AcostaEet\u00a0al.Elvitegravir\/Cobicistat pharmacokinetics in pregnancy and postpartum.CROI2017;Seattle WA 2017[Abstract 755]."},{"key":"e_1_2_10_6_1","unstructured":"RyomL LundgrenJD El\u2010SadrWet\u00a0al.Association between cardiovascular disease & contemporarily used protease inhibitors.CROI2017;Seattle WA 2017."},{"key":"e_1_2_10_7_1","unstructured":"EACS Guidelines version 8.2. 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