{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:24:20Z","timestamp":1740126260145,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:00:00Z","timestamp":1531267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We investigated the trend in usage of post\u2010exposure prophylaxis (<jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content>) after <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u20101 risk exposure and evaluated <jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content> prescription decision making of physicians according to guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All <jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content> consultations from January 2014 to December 2016 in patients presenting at the University Hospital of Cologne (Germany) were retrospectively analysed. <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> risk contacts included sexual and occupational exposure. The European <jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content> Clinical Society (<jats:styled-content style=\"fixed-case\">EACS<\/jats:styled-content>) Guidelines for <jats:styled-content style=\"fixed-case\">HIV PEP<\/jats:styled-content> (version 9.0, 2017) were used for assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 649 patients presented at the emergency department (<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>) or the clinic for infectious diseases (<jats:styled-content style=\"fixed-case\">IDC<\/jats:styled-content>) for <jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content> consultations. A continuous increase in the number of <jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content> requests was recorded: 189 in 2014, 208 in 2015 and 252 in 2016. <jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content> consultations in men who have sex with men (<jats:styled-content style=\"fixed-case\">MSM<\/jats:styled-content>) showed a remarkable increase in 2016 (2014, <jats:italic>n<\/jats:italic> = 96; 2015, <jats:italic>n<\/jats:italic> = 101; 2016, <jats:italic>n<\/jats:italic> = 152). Decisions taken by physicians with a specialization in infectious diseases (<jats:italic>n<\/jats:italic> = 547) included 61 (11%) guideline\u2010discordant prescriptions [2014: 14% (<jats:italic>n<\/jats:italic> = 22); 2015: 9% (<jats:italic>n<\/jats:italic> = 16); 2016: 11% (<jats:italic>n<\/jats:italic> = 23)]. Among these, sexual exposure accounted for 45 (74%) cases, including 15 cases of nonconsensual sex, while occupational exposure accounted for 14 (23%) cases and other exposure two cases (3%). The main reason for guideline\u2010discordant <jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content> prescriptions was emotional stress of the patient (<jats:italic>n<\/jats:italic> = 37\/61).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content> prescriptions are increasing and decision making is influenced by patients\u2019 emotional stress, but <jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content> prescriptions should be strictly administered according to risk assessment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12645","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T10:55:12Z","timestamp":1531306512000},"page":"645-653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["To prescribe, or not to prescribe: decision making in HIV\u20101 post\u2010exposure prophylaxis"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1787-6212","authenticated-orcid":false,"given":"M","family":"Scholten","sequence":"first","affiliation":[{"name":"Department I of Internal Medicine University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Platten","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine University of Cologne Cologne Germany"},{"name":"German Center for Infection Research (DZIF) Partner Site Bonn\u2010Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"K\u00fcmmerle","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine University of Cologne Cologne Germany"},{"name":"Practice Ebertplatz Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Jung","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine University of Cologne Cologne Germany"},{"name":"German Center for Infection Research (DZIF) Partner Site Bonn\u2010Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Wyen","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine University of Cologne Cologne Germany"},{"name":"Practice Ebertplatz Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Ernst","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics and Computational Biology University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Horn","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Burst","sequence":"additional","affiliation":[{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Rybniker","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine University of Cologne Cologne Germany"},{"name":"German Center for Infection Research (DZIF) Partner Site Bonn\u2010Cologne Cologne Germany"},{"name":"Center for Molecular Medicine Cologne (CMMC) University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"F\u00e4tkenheuer","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine University of Cologne Cologne Germany"},{"name":"German Center for Infection Research (DZIF) Partner Site Bonn\u2010Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine University of Cologne Cologne Germany"},{"name":"German Center for Infection Research (DZIF) Partner Site Bonn\u2010Cologne Cologne Germany"},{"name":"Center for Molecular Medicine Cologne (CMMC) University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009021"},{"key":"e_1_2_5_3_1","unstructured":"World Health Organization.Number of new HIV infections. Data by WHO region.2015. Available athttp:\/\/apps.who.int\/gho\/data\/view.main.HIVINCIDENCEREGIONv?lang=en(accessed 01 April 2018)."},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711203372101"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ068"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2014.08.005"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200202150-00011"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001265"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2016.21.43.30382"},{"key":"e_1_2_5_10_1","unstructured":"European AIDS Clinical Society. Version 9.02017. Available athttp:\/\/www.eacsociety.org\/files\/guidelines_9.0-english.pdf(accessed 01 April 2018)."},{"key":"e_1_2_5_11_1","unstructured":"Deutsche AIDS\u2010Gesellschaft \u00d6sterreichische AIDS Gesellschaft.Deutsch\u2010\u00d6sterreichische Leitlinien zur Postexpositionellen Prophylaxe der HIV\u2010Infektion.pdf 2013. Available athttp:\/\/www.daignet.de\/site-content\/hiv-therapie\/leitlinien-1\/Deutsch_Osterreichische%20Leitlinien%20zur%20Postexpositionellen%20Prophylaxe%20der%20HIV_Infektion.pdf(accessed 01 April 2018)."},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12363"},{"key":"e_1_2_5_13_1","unstructured":"Center for Disease Control and Prevention (CDC).Statistics overview. International statistics. CDC. Available athttps:\/\/www.cdc.gov\/hiv\/statistics\/overview\/index.html(accessed 01 April 2018)."},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/v3040347"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.2196\/publichealth.7546"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11524-017-0175-9"},{"key":"e_1_2_5_17_1","unstructured":"Robert Koch Institut.Survstat 2.0. Available athttps:\/\/survstat.rki.de(accessed 01 April 2018)."},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12369"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200404150-00010"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2008.033662"},{"key":"e_1_2_5_21_1","unstructured":"DoddsC HammondG KeoghP HicksonF WeatherburnP.PEP talk Awareness of and access to post\u2010exposure prophylaxis among Gay & Bisexual men in the UK. Available atwww.sigmaresearch.org.uk\/downloads\/report06d.pdf(accessed 01 April 2018)."},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-015-1237-1"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-018-1127-3"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087674"},{"key":"e_1_2_5_25_1","first-page":"147","article-title":"Current perspectives in HIV post\u2010exposure prophylaxis","volume":"6","author":"Sultan B","year":"2014","journal-title":"HIV AIDS (Auckl)"},{"key":"e_1_2_5_26_1","unstructured":"MolinaJM CharreauB SpireLet al.Durban South AfricaJuly2016Efficacy of on demand PrEP with TDF\u2010FTC in the ANRS IPERGAY open\u2010label extension study. AIDS 2016 Conference."},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-010-9712-1"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2008.00670.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199809000-00014"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000298"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-8080(03)02285-7"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-002836"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhiv.12645","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.12645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T01:13:33Z","timestamp":1694999613000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.12645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,11]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/hiv.12645"],"URL":"https:\/\/doi.org\/10.1111\/hiv.12645","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"type":"print","value":"1464-2662"},{"type":"electronic","value":"1468-1293"}],"subject":[],"published":{"date-parts":[[2018,7,11]]},"assertion":[{"value":"2018-05-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}