{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:24:20Z","timestamp":1740126260766,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T00:00:00Z","timestamp":1535587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005111","name":"Rigshospitalet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005275","name":"Region Hovedstaden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","award":["126"],"award-info":[{"award-number":["126"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2018,11]]},"abstract":"Objectives<\/jats:title>Chronic obstructive pulmonary disease (COPD<\/jats:styled-content>) is underdiagnosed in the general population and possibly also in people living with HIV<\/jats:styled-content> (PLWH<\/jats:styled-content>). We evaluated the diagnostic performance of symptoms and risk factors for assessment of airflow limitation in PLWH<\/jats:styled-content> and in uninfected controls.<\/jats:p><\/jats:sec>Methods<\/jats:title>Spirometry was performed in the Copenhagen Comorbidity in HIV<\/jats:styled-content> Infection (COCOMO<\/jats:styled-content>) study and Copenhagen General Population Study (CGPS<\/jats:styled-content>), and airflow limitation was defined by forced expiratory volume in 1 s\/forced vital capacity < lower limit of normal. We calculated the sensitivity, specificity, predictive values and area under the curve (AUC<\/jats:styled-content>) of symptoms and risk factors for assessment of airflow limitation in PLWH<\/jats:styled-content> and uninfected controls.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 1083 PLWH<\/jats:styled-content> and 12 074 uninfected controls were included in the study. The sensitivity for sputum, chronic cough, breathlessness, wheezing, current and cumulative smoking and self\u2010reported COPD<\/jats:styled-content> was higher, but the specificity lower, in PLWH<\/jats:styled-content> than in uninfected controls. The negative and positive predictive values were largely similar between the groups. The AUC<\/jats:styled-content>s were similar or slightly higher in PLWH<\/jats:styled-content> and highest for > 20 pack\u2010years smoked [0.65; 95% confidence interval (CI<\/jats:styled-content>) 0.58\u20130.72] and wheezing (0.64; 95% CI<\/jats:styled-content> 0.57\u20130.71). A summed score for five variables was associated with slightly higher AUC<\/jats:styled-content> in PLWH<\/jats:styled-content> compared with uninfected controls [0.71 (95% CI<\/jats:styled-content> 0.63\u20130.79) versus 0.65 (95% CI<\/jats:styled-content> 0.63\u20130.68), respectively; P<\/jats:italic> = 0.06].<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Clinical variables were relatively poor discriminators of airflow limitation in PLWH<\/jats:styled-content> and uninfected controls. Active COPD<\/jats:styled-content> case finding by screening for symptoms and relevant exposures, as recommended in the general population, is likely to yield similar diagnostic power in PLWH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12669","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T15:27:34Z","timestamp":1535642854000},"page":"751-755","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic performance of clinical characteristics to detect airflow limitation in people living with HIV<\/scp> and in uninfected controls"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8960-7524","authenticated-orcid":false,"given":"A","family":"Ronit","sequence":"first","affiliation":[{"name":"Viro\u2010immunology Research Unit Department of Infectious Diseases Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Benfield","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hvidovre Hospital University of Copenhagen Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Mocroft","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research Epidemiology, Modelling and Evaluation (CREME) Institute for Global Health University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Gerstoft","sequence":"additional","affiliation":[{"name":"Viro\u2010immunology Research Unit Department of Infectious Diseases Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BG","family":"Nordestgaard","sequence":"additional","affiliation":[{"name":"The Copenhagen General Population Study Department of Clinical Biochemistry Herlev and Gentofte Hospital Copenhagen University Hospital Herlev Denmark"},{"name":"Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Vestbo","sequence":"additional","affiliation":[{"name":"Division of Infection, Immunity and Respiratory Medicine University of Manchester Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6391-7455","authenticated-orcid":false,"given":"SD","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Viro\u2010immunology Research Unit Department of Infectious Diseases Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Copenhagen Co\u2010morbidity in HIV Infection (COCOMO) Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61728-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00214-2017"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-211079"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-2535"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.115725"},{"key":"e_1_2_7_7_1","unstructured":"http:\/\/www.eacsociety.org\/files\/guidelines_9.0-english.pdf."},{"key":"e_1_2_7_8_1","unstructured":"http:\/\/legacy.screening.nhs.uk\/copd. 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