{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:47Z","timestamp":1787014307856,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T00:00:00Z","timestamp":1536019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005977","name":"Kaiser Permanente","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K01 122853"],"award-info":[{"award-number":["K01 122853"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2019,1]]},"abstract":"\n Objectives<\/jats:title>\n \n We evaluated the association of\n HIV<\/jats:styled-content>\n infection and immunodeficiency with acute coronary syndrome (\n ACS<\/jats:styled-content>\n ) recurrence, and with all\u2010cause mortality as a secondary outcome, after hospitalization for\n ACS<\/jats:styled-content>\n among\n HIV<\/jats:styled-content>\n \u2010infected and\n HIV<\/jats:styled-content>\n \u2010uninfected individuals.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We conducted a retrospective cohort study within Kaiser Permanente Northern California of\n HIV<\/jats:styled-content>\n \u2010infected and\n HIV<\/jats:styled-content>\n \u2010uninfected adults discharged after\n ACS<\/jats:styled-content>\n hospitalization [types:\n ST<\/jats:styled-content>\n \u2010elevation myocardial infarction (\n STEMI<\/jats:styled-content>\n ), non\u2010\n STEMI<\/jats:styled-content>\n , or unstable angina] during 1996\u20132010. We compared the outcomes of\n ACS<\/jats:styled-content>\n recurrence and all\u2010cause mortality within 3\u00a0years, both overall by\n HIV<\/jats:styled-content>\n status and stratified by recent\n CD<\/jats:styled-content>\n 4 count, with\n HIV<\/jats:styled-content>\n \u2010uninfected individuals as the reference group. Hazard ratios (\n HR<\/jats:styled-content>\n s) were obtained from Cox regression models with adjustment for age, sex, race\/ethnicity, year,\n ACS<\/jats:styled-content>\n type, smoking, and cardiovascular risk factors.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 226\n HIV<\/jats:styled-content>\n \u2010infected and 86\u00a0321\n HIV<\/jats:styled-content>\n \u2010uninfected individuals with\n ACS<\/jats:styled-content>\n ,\n HIV<\/jats:styled-content>\n \u2010infected individuals had a similar risk of\n ACS<\/jats:styled-content>\n recurrence compared with\n HIV<\/jats:styled-content>\n \u2010uninfected individuals [\n HR<\/jats:styled-content>\n 1.08; 95% confidence interval (\n CI<\/jats:styled-content>\n ) 0.76\u20101.54].\n HIV<\/jats:styled-content>\n infection was independently associated with all\u2010cause mortality after\n ACS<\/jats:styled-content>\n hospitalization overall (\n HR<\/jats:styled-content>\n 2.52; 95%\n CI<\/jats:styled-content>\n 1.81\u20133.52). In\n CD<\/jats:styled-content>\n 4\u2010stratified models, post\u2010\n ACS<\/jats:styled-content>\n mortality was higher for\n HIV<\/jats:styled-content>\n \u2010infected individuals with\n CD<\/jats:styled-content>\n 4 counts of 201\u2013499 cells\/\u03bcL (\n HR<\/jats:styled-content>\n 2.64; 95%\n CI<\/jats:styled-content>\n 1.66\u20134.20) and <\u00a0200 cells\/\u03bcL (\n HR<\/jats:styled-content>\n 5.41; 95%\n CI<\/jats:styled-content>\n 3.14\u20139.34), but not those with CD4 counts \u2265\u00a0500 cells\/\u03bcL (\n HR<\/jats:styled-content>\n 0.67; 95%\n CI<\/jats:styled-content>\n 0.22\u20132.08), compared with\n HIV<\/jats:styled-content>\n \u2010uninfected individuals (\n P<\/jats:italic>\n trend <\u00a00.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n HIV<\/jats:styled-content>\n infection and immunodeficiency were not associated with recurrence of\n ACS<\/jats:styled-content>\n after hospitalization. All\u2010cause mortality was higher among\n HIV<\/jats:styled-content>\n \u2010infected compared with\n HIV<\/jats:styled-content>\n \u2010uninfected individuals, but there was no excess mortality risk among\n HIV<\/jats:styled-content>\n \u2010infected individuals with high\n CD<\/jats:styled-content>\n 4 counts.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hiv.12670","type":"journal-article","created":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T06:04:31Z","timestamp":1536041071000},"page":"19-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Recurrence after hospitalization for acute coronary syndrome among\n HIV<\/scp>\n \u2010infected and\n HIV<\/scp>\n \u2010uninfected individuals"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8552-414X","authenticated-orcid":false,"given":"JL","family":"Marcus","sequence":"first","affiliation":[{"name":"Harvard Medical School 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