{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T17:25:10Z","timestamp":1768325110061,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the study was to compare the efficacy and tolerability of switching antiretroviral therapy to dolutegravir + emtricitabine\/tenofovir disoproxil fumarate (<jats:styled-content style=\"fixed-case\">TDF<\/jats:styled-content>) with those of switching to elvitegravir\/cobicistat\/emtricitabine\/<jats:styled-content style=\"fixed-case\">TDF<\/jats:styled-content> in clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a multicentre real\u2010life observational study, we analysed data for <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients on antiretroviral treatment with viral load &lt; 50 HIV\u20101 RNA copies\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> switching to dolutegravir + emtricitabine\/<jats:styled-content style=\"fixed-case\">TDF<\/jats:styled-content> (dolutegravir group) or elvitegravir\/cobicistat\/emtricitabine\/<jats:styled-content style=\"fixed-case\">TDF<\/jats:styled-content> (elvitegravir group). Follow\u2010up was censored at 48 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 48\u2010week estimated proportion maintaining virological efficacy was 96.1% with dolutegravir (<jats:italic>n<\/jats:italic> = 123) and 95.4% with elvitegravir (<jats:italic>n<\/jats:italic> = 186; <jats:italic>P<\/jats:italic> = 0.941). Patients in the dolutegravir group showed more treatment discontinuations, but these were mainly as a result of simplification. The elvitegravir group showed more discontinuations because of renal adverse events (2.7% versus 0% with dolutegravir). Interestingly, no difference was observed between the two regimens in central nervous system toxicity\u2010related discontinuations. Switching to dolutegravir was associated with a better blood lipid profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Switching to dolutegravir + emtricitabine\/<jats:styled-content style=\"fixed-case\">TDF<\/jats:styled-content> was associated with similar efficacy and tolerability to switching to elvitegravir\/cobicistat\/emtricitabine\/<jats:styled-content style=\"fixed-case\">TDF<\/jats:styled-content> in virologically suppressed patients in clinical practice, although reasons for discontinuation showed differences between regimens. These results should be interpreted with caution, as this is a nonrandomized comparison.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12688","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T10:38:58Z","timestamp":1542710338000},"page":"164-168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Efficacy and safety of switching to dolutegravir plus emtricitabine\/tenofovir disoproxil fumarate (<scp>TDF<\/scp>) or elvitegravir\/cobicistat\/emtricitabine\/<scp>TDF<\/scp> in virologically suppressed <scp>HIV<\/scp>\u2010infected patients in clinical practice: results from a multicentre, observational study"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4623-9976","authenticated-orcid":false,"given":"G","family":"Baldin","sequence":"first","affiliation":[{"name":"Institute of Clinical Infectious Diseases Fondazione Policlinico Universitario A. Gemelli IRCCS Catholic University of the Sacred Heart Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5941-883X","authenticated-orcid":false,"given":"A","family":"Ciccullo","sequence":"additional","affiliation":[{"name":"Institute of Clinical Infectious Diseases Fondazione Policlinico Universitario A. Gemelli IRCCS Catholic University of the Sacred Heart Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Capetti","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Infectious Diseases Luigi Sacco University Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Rusconi","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit DIBIC Luigi Sacco University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0385-0903","authenticated-orcid":false,"given":"G","family":"Sterrantino","sequence":"additional","affiliation":[{"name":"Division of Tropical and Infectious Diseases \u2018Careggi\u2019 Hospital Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MV","family":"Cossu","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Infectious Diseases Luigi Sacco University Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3685-4289","authenticated-orcid":false,"given":"A","family":"Giacomelli","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit DIBIC Luigi Sacco University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Lagi","sequence":"additional","affiliation":[{"name":"Division of Tropical and Infectious Diseases \u2018Careggi\u2019 Hospital Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Latini","sequence":"additional","affiliation":[{"name":"Infectious Dermatology and Allergology Unit IFO S. Gallicano Institute (IRCCS) Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Bagella","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Sassari Sassari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"De Luca","sequence":"additional","affiliation":[{"name":"University Division of Infectious Diseases Siena University Hospital Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Di Giambenedetto","sequence":"additional","affiliation":[{"name":"Institute of Clinical Infectious Diseases Fondazione Policlinico Universitario A. 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