{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:24:55Z","timestamp":1784543095524,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T00:00:00Z","timestamp":1543795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the study was to assess whether the timing of combination antiretroviral therapy (<jats:styled-content style=\"fixed-case\">cART<\/jats:styled-content>) initiation, the choice of <jats:styled-content style=\"fixed-case\">cART<\/jats:styled-content> and virological response differ in migrants versus European natives in the north and east of Paris area, after dissemination of French recommendations for universal treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Antiretroviral therapy\u2010na\u00efve <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u20101\u2010infected adults with at least two follow\u2010up visits at one of 15 participating centres between 1 January 2014 and 31 March 2015 were included in the study. Factors associated with <jats:styled-content style=\"fixed-case\">cART<\/jats:styled-content> initiation before 31 March 2015, with protease inhibitor (<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>)\u2010containing <jats:styled-content style=\"fixed-case\">cART<\/jats:styled-content> among individuals initiating <jats:styled-content style=\"fixed-case\">cART<\/jats:styled-content>, and with 1\u2010year virological success after <jats:styled-content style=\"fixed-case\">cART<\/jats:styled-content> initiation were assessed using multivariable logistic regression models. Sex, age, region of origin [Western Europe, sub\u2010Saharan Africa (<jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content>) or other], <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> transmission group, baseline <jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content> status, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 cell count and plasma viral load (<jats:styled-content style=\"fixed-case\">VL<\/jats:styled-content>), and hepatitis B and\/or C virus infection were considered in the analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 912 individuals, only 584 (64%) started <jats:styled-content style=\"fixed-case\">cART<\/jats:styled-content> during the study period. After adjustment, migrants from <jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content> were half as likely to initiate <jats:styled-content style=\"fixed-case\">cART<\/jats:styled-content> and to have a subsequent virological response compared with individuals from Western Europe [adjusted odds ratio (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>) 0.54; 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 0.36\u20130.82; and <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> 0.52; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.28\u20130.98, respectively]. <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>\u2010containing <jats:styled-content style=\"fixed-case\">cART<\/jats:styled-content> was more frequently prescribed in migrants from <jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content>, in people with lower <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 cell counts and in people with higher VL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Even in the context of universal <jats:styled-content style=\"fixed-case\">cART<\/jats:styled-content> recommendations and of free access to care, migrants from <jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content> still have delayed access to <jats:styled-content style=\"fixed-case\">cART<\/jats:styled-content> and a lower virological response. Efforts are still necessary to provide immediate <jats:styled-content style=\"fixed-case\">cART<\/jats:styled-content> to all people living with HIV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12697","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T09:28:48Z","timestamp":1543829328000},"page":"175-181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Does region of origin influence the timing and outcome of first\u2010line antiretroviral therapy in France?"],"prefix":"10.1111","volume":"20","author":[{"given":"C","family":"Gatey","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Saint\u2010Louis Hospital AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Brun","sequence":"additional","affiliation":[{"name":"Est Paris Area COREVIH (Regional Coordination of the fight against HIV infection) Saint Louis Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Hamet","sequence":"additional","affiliation":[{"name":"Est Paris Area COREVIH (Regional Coordination of the fight against HIV infection) Saint Louis Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Diamantis","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Marc Jacquet Hospital Melun France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Sellier","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Saint Louis\u2010Lariboisi\u00e8re\u2010Fernand Widal Hospital AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Bouchaud","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Avicenne Hospital AP\u2010HP Bobigny France"},{"name":"Laboratory Health Education and Practice (LEPS EA 3412) Paris 13 University Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Garrait","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Intercommunal Hospital Centre Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Rozenbaum","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Saint\u2010Louis Hospital AP\u2010HP Paris France"},{"name":"Est Paris Area COREVIH (Regional Coordination of the fight against HIV infection) Saint Louis Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JM","family":"Molina","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Saint\u2010Louis Hospital AP\u2010HP Paris France"},{"name":"University of Paris Diderot Sorbonne Paris University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7891-7594","authenticated-orcid":false,"given":"S","family":"Abgrall","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Antoine B\u00e9cl\u00e8re Hospital Clamart France"},{"name":"University of Paris Saclay Paris\u2010Sud University UVSQ Le Kremlin\u2010Bic\u00eatre France"},{"name":"CESP INSERM U1018 Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the COREVIH Ile de France Est Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,3]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"MorlatP le groupe d'experts sur l'infection \u00e0 VIH.Prise en charge m\u00e9dicale des personnes infect\u00e9es par le VIH. 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