{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:58:20Z","timestamp":1792677500979,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008240","name":"Fonds de Recherche du Qu\u00e9bec-Soci\u00e9t\u00e9 et Culture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008240","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2019,3]]},"abstract":"Objectives<\/jats:title>The reported prevalence of chronic obstructive pulmonary disease (COPD<\/jats:styled-content>) in people living with HIV<\/jats:styled-content> (PLWHIV<\/jats:styled-content>) varies widely. Our objective was to estimate the prevalence of airflow obstruction and COPD<\/jats:styled-content> in unselected PLWHIV<\/jats:styled-content> and identify characteristics that increase the risk of nonreversible airflow obstruction in order to guide case finding strategies for COPD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>All adults attending the Chronic Viral Illness Service were invited to participate in the study, regardless of smoking status or history of known COPD<\/jats:styled-content>\/asthma. Individuals underwent spirometric testing both before and after use of a salbutamol bronchodilator. Airflow obstruction was defined as forced expiratory volume in 1 s (FEV<\/jats:styled-content>1<\/jats:sub>)\/forced vital capacity (FVC<\/jats:styled-content>) < 0.7 post\u2010bronchodilation, whereas COPD<\/jats:styled-content> was defined as FEV<\/jats:styled-content>1<\/jats:sub>\/FVC<\/jats:styled-content> < 0.7 post\u2010bronchodilation and Medical Research Council (MRC<\/jats:styled-content>) score > 2. Multivariate logistic regression was used to evaluate risk factors associated with airflow obstruction, reported as adjusted odds ratios (aORs<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Five hundred and three participants successfully completed spirometry testing. The median (Q1; Q3) age was 52 (44; 58) years. The median (Q1; Q3) CD<\/jats:styled-content>4 count was 598 (438; 784) cells\/\u03bcL and the median (Q1; Q3) nadir CD<\/jats:styled-content>4 count was 224 (121; 351) cells\/\u03bcL. There were 119 (24%) current smokers and 145 (29%) former smokers. Among those screened, 54 (11%) had airflow obstruction whereas three (1%) of the participants had COPD<\/jats:styled-content>. Factors that were associated with airflow obstruction included a history of smoking [aOR<\/jats:styled-content> 2.2; 95% confidence interval (CI<\/jats:styled-content>) 1.1; 4.7], older age (aOR 1.6; 95% CI 1.2; 2.2), and lower CD<\/jats:styled-content>4 count (aOR 0.8; 95% CI 0.7; 1.0).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Airflow obstruction was relatively uncommon. Our findings suggest that PLWHIV<\/jats:styled-content> who are \u226550 years old, smokers and those with nadir CD<\/jats:styled-content>4 counts \u2264 200 cells\/\u03bcL could be targeted to undergo spirometry to diagnose chronic airflow obstruction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12699","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T05:16:48Z","timestamp":1547011008000},"page":"192-201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prevalence and predictors of airflow obstruction in an HIV<\/scp> tertiary care clinic in Montreal, Canada: a cross\u2010sectional study"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4547-714X","authenticated-orcid":false,"given":"CT","family":"Costiniuk","sequence":"first","affiliation":[{"name":"Chronic Viral Illness Service\/Division of Infectious Diseases Research Institute of the McGill 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