{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:08:07Z","timestamp":1790759287362,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2019,3]]},"abstract":"Objectives<\/jats:title>We examined trends in the incidence rates of invasive cervical cancer (ICC<\/jats:styled-content>) and in the rate of survival after ICC<\/jats:styled-content> among women living with HIV<\/jats:styled-content> (WLHIV<\/jats:styled-content>) in France and compared them to those of the general population.<\/jats:p><\/jats:sec>Methods<\/jats:title>Histologically validated incident cases of ICC<\/jats:styled-content> in the period 1992\u20132009 from the French Hospital Database on HIV<\/jats:styled-content> (FHDH<\/jats:styled-content>\u2010ANRS CO4) were included in the study. Age\u2010standardized incidence rates were estimated for FHDH<\/jats:styled-content> and the general population in France for 1992\u20131996 [pre\u2010combination antiretroviral therapy (cART<\/jats:styled-content>) period], 1997\u20132000 (early cART<\/jats:styled-content> period), 2001\u20132004 (intermediate cART<\/jats:styled-content> period), and 2005\u20132009 (late cART<\/jats:styled-content> period). Age\u2010standardized incidence ratios (SIR<\/jats:styled-content>s) were calculated. Five\u2010year survival was compared with that of the general population for ICC<\/jats:styled-content> diagnosed in 2005\u20132009 after standardization for age.<\/jats:p><\/jats:sec>Results<\/jats:title>Among 28\u00a0977 WLHIV<\/jats:styled-content>, 60 incident ICC<\/jats:styled-content>s were histologically validated. There was a nonsignificant decreasing trend for the incidence across the cART<\/jats:styled-content> periods (P<\/jats:italic>\u00a0=\u00a00.07), from 60 to 36\/100\u00a0000 person\u2010years. The risk of ICC<\/jats:styled-content> was consistently significantly higher in WLHIV<\/jats:styled-content> than in the general population; the SIR<\/jats:styled-content> was 5.4 [95% confidence interval (CI<\/jats:styled-content>) 3.0\u20138.9] during the pre\u2010cART<\/jats:styled-content> period and 3.3 (95% CI<\/jats:styled-content> 2.2\u20134.7) in 2005\u20132009. Survival after ICC<\/jats:styled-content> did not improve across periods (log\u2010rank P<\/jats:italic>\u00a0=\u00a00.14), with overall estimated 5\u2010year survival of 78% (95% CI<\/jats:styled-content> 0.67\u20130.89%). Five\u2010year survival was similar for WLHIV<\/jats:styled-content> and the general population for women diagnosed with ICC<\/jats:styled-content> in 2005\u20132009, after standardization (P<\/jats:italic>\u00a0=\u00a00.45).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>ICC risk is still more than three times higher in WLHIV<\/jats:styled-content> than in the general population. Survival after ICC<\/jats:styled-content> did not improve over time and was similar to that of the general population during the most recent period. Such results call for promotion of the uptake of screening in WLHIV<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12703","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T04:15:09Z","timestamp":1548735309000},"page":"222-229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Invasive cervical cancer in HIV<\/scp>\u2010infected women: risk and survival relative to those of the general population in France. Results from the French Hospital Database on HIV<\/scp> (FHDH<\/scp>)\u2013Agence Nationale de Recherches sur le SIDA et les H\u00e9patites Virales (ANRS) CO<\/scp>4 cohort study"],"prefix":"10.1111","volume":"20","author":[{"given":"S.","family":"Grabar","sequence":"first","affiliation":[{"name":"Sorbonne University INSERM IPLESP (Pierre Louis Institute of Public Health) Paris France"},{"name":"Unit of Biostatistic and Epidemiology Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Paris Centre University Hospitals Paris Descartes University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hleyhel","sequence":"additional","affiliation":[{"name":"CERIPH Center for Research in Public Health Pharmacoepidemiology Surveillance Unit Faculty of Public Health Lebanese University Fanar Lebanon"},{"name":"INSPECT\u2010LB National Public Health Institute Clinical Epidemiology and Toxicology Faculty of Public Health Lebanese University Fanar 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