{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:49:58Z","timestamp":1770490198181,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T00:00:00Z","timestamp":1562284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Since 2013, the London HIV Mortality Review Group has conducted annual reviews of deaths among people with HIV to reduce avoidable mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All London HIV care Trusts reported data on 2016 patient deaths in 2017. Deaths were submitted using a modified Causes of Death in HIV reporting form and categorized by a specialist HIV pathologist and two HIV clinicians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 206 deaths reported; 77% were among men. Median age at death was 56\u00a0years. Cause was established for 82% of deaths, with non\u2010AIDS\u2010related malignancies and AIDS\u2010defining illnesses being the most common causes reported. Risk factors in the year before death included: tobacco smoking (37%), excessive alcohol consumption (19%), non\u2010injecting drug use (10%), injecting drug use (7%) and opioid substitution therapy (6%). Thirty\u2010nine per cent of patients had a history of depression, 33% chronic hypertension, 27% dyslipidaemia, 17% coinfection with hepatitis B virus and\/or hepatitis C virus and 14% diabetes mellitus. At the time of death, 81% of patients were on antiretroviral therapy (ART), 61% had a CD4 count &lt;\u00a0350 cells\/\u03bcL, and 24% had a viral load \u2265\u00a0200 HIV\u20101 RNA copies\/mL. Thirty\u2010six per cent of deaths were unexpected; 61% of expected deaths were in hospital. Two\u2010thirds of expected deaths had a prior end\u2010of\u2010life care discussion documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In 2016, most deaths were attributable to non\u2010AIDS\u2010related conditions and the majority of patients were on ART and virally suppressed. However, several potentially\u00a0preventable deaths were identified and underlying risk factors were common. As London HIV patients are not representative of people with HIV in the UK, a national mortality review is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12761","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T11:08:20Z","timestamp":1562324900000},"page":"628-633","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cause of death among HIV patients in London in 2016"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2220-623X","authenticated-orcid":false,"given":"S","family":"Croxford","sequence":"first","affiliation":[{"name":"National Infection Service Public Health England London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RF","family":"Miller","sequence":"additional","affiliation":[{"name":"Central and North West London NHS Foundation Trust Mortimer Market Centre London 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