{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:50:22Z","timestamp":1762624222882,"version":"3.40.5"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T00:00:00Z","timestamp":1564358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2019,10]]},"abstract":"Objectives<\/jats:title>We sought to examine the association between dispensation of methadone maintenance therapy (MMT<\/jats:styled-content>) and antiretroviral therapy (ART<\/jats:styled-content>) at the same facility, across multiple low\u2010barrier dispensing outlets, and achieving optimal adherence to ART<\/jats:styled-content> among people who use illicit drugs (PWUD<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>We used data from the AIDS Care Cohort to Evaluate Exposure to Survival Services (ACCESS<\/jats:styled-content>) study, a long\u2010running study of a community\u2010recruited cohort of HIV<\/jats:styled-content>\u2010positive PWUD<\/jats:styled-content>, linked to comprehensive HIV<\/jats:styled-content> clinical records in Vancouver, Canada, a setting of no\u2010cost, universal access to HIV<\/jats:styled-content> care. The longitudinal relationship between MMT<\/jats:styled-content>\u2010ART<\/jats:styled-content> dispensation at the same facility and the odds of \u2265\u00a095% ART<\/jats:styled-content> adherence was analysed using multivariable generalized linear mixed\u2010effects modelling. We conducted a further analysis using a marginal structural mode with inverse probability of treatment weights as a sensitivity analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>This study included data on 1690 interviews of 345 ART<\/jats:styled-content>\u2010 and MMT<\/jats:styled-content>\u2010exposed participants carried out between June 2012 and December 2017. In the final multivariable model, MMT<\/jats:styled-content>\u2010ART<\/jats:styled-content> dispensation, compared with nondispensation at the same facility, was associated with greater odds of achieving \u2265\u00a095% adherence [adjusted odds ratio (AOR<\/jats:styled-content>) 1.56; 95% confidence interval (CI<\/jats:styled-content>) 1.26\u20131.96]. A marginal structural model estimated a 1.48 (95% CI<\/jats:styled-content> 1.15\u20131.80) greater odds of \u2265\u00a095% adherence among participants who reported MMT<\/jats:styled-content>\u2010ART<\/jats:styled-content> dispensation at the same facility compared with those who did not.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The odds of achieving optimal adherence to ART<\/jats:styled-content> were 56% higher during periods in which MMT<\/jats:styled-content> and ART<\/jats:styled-content> medications were dispensed at the same facility, in a low\u2010barrier setting. Our findings highlight the need to consider a simpler integrated approach with medication dispensation at the same facility in low\u2010threshold settings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12777","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T04:40:13Z","timestamp":1564461613000},"page":"606-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Dispensation of antiretroviral therapy and methadone maintenance therapy at the same facility in a low\u2010barrier setting linked to optimal adherence to HIV<\/scp> treatment"],"prefix":"10.1111","volume":"20","author":[{"given":"NA","family":"Mohd Salleh","sequence":"first","affiliation":[{"name":"Interdisciplinary Studies Graduate Program University of British Columbia Vancouver BC Canada"},{"name":"BC Centre on Substance Use Vancouver BC Canada"},{"name":"Department of Social and Preventive Medicine, Faculty of Medicine 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