{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:29:20Z","timestamp":1765758560572,"version":"3.40.5"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T00:00:00Z","timestamp":1563408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Wilhelm and Martina Lundgren Foundation"},{"name":"the Swedish International Development Cooperation Agency"},{"name":"the Assar Gabrielsson Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>In this study, we determined the incidence and persistence of human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) strains and of squamous intraepithelial lesions (<jats:styled-content style=\"fixed-case\">SIL<\/jats:styled-content>) or worse cytology in 237 <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive and <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010negative Rwandan women and whether the interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201028B single nucleotide polymorphism (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>) at rs12979860 correlated with susceptibility to and persistence of <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cervical samples were collected at baseline and after 9, 18 and 24\u00a0months for a 40\u2010<jats:styled-content style=\"fixed-case\">HPV DNA<\/jats:styled-content> screening test and a ThinPrep Pap test. Genotyping of the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201028B <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> rs12979860 was performed using real\u2010time polymerase chain reaction (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Chronic high\u2010risk (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infections occurred in 56% of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive women, while no <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010negative women developed <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> chronicity. High\u2010grade <jats:styled-content style=\"fixed-case\">SIL<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>) or cancer was diagnosed in 38% of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive women with persistent <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infections. <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> positivity at baseline were factors associated with an increased risk of <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> persistence. Additionally, <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> positivity at baseline was associated with an increased risk of developing <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content> or worse cytology. The unfavourable T\/x genotype at rs12979860 is common among Africans, and women with this genotype were found to be more commonly infected with <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HPV screening in Rwanda may help to identify women at risk of developing cervical cancer and polymorphism in <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201028B may be associated with risk of contracting\u00a0 <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12782","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T10:16:29Z","timestamp":1563444989000},"page":"485-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Persistence rate of cervical human papillomavirus infections and abnormal cytology in Rwanda"],"prefix":"10.1111","volume":"20","author":[{"given":"MF","family":"Mukanyangezi","sequence":"first","affiliation":[{"name":"Department of Pharmacology Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden"},{"name":"College of Medicine and Health Sciences University of Rwanda Kigali Rwanda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Rugwizangoga","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences University of Rwanda Kigali Rwanda"},{"name":"Tumour Immunology (TIMM) Laboratory Sahlgrenska Cancer Center, Department of Infectious Diseases, Institute of Biomedicine Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden"},{"name":"University Teaching Hospital of Kigali (CHUK) Kigali Rwanda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Manzi","sequence":"additional","affiliation":[{"name":"University Teaching Hospital of Kigali (CHUK) Kigali Rwanda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Rulisa","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences University of Rwanda Kigali Rwanda"},{"name":"University Teaching Hospital of Kigali (CHUK) Kigali Rwanda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Hellstrand","sequence":"additional","affiliation":[{"name":"Tumour Immunology (TIMM) Laboratory Sahlgrenska Cancer Center, Department of Infectious Diseases, Institute of Biomedicine Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Tobin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Martner","sequence":"additional","affiliation":[{"name":"Tumour Immunology (TIMM) Laboratory Sahlgrenska Cancer Center, Department of Infectious Diseases, Institute of Biomedicine Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Bienvenu","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences University of Rwanda Kigali Rwanda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1349-9336","authenticated-orcid":false,"given":"D","family":"Giglio","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden"},{"name":"Department of Oncology Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.12.958"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.11.796"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12564"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.srhc.2015.11.006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/v9120390"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.11.006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08309"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08463"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11262-017-1527-y"},{"key":"e_1_2_6_12_1","first-page":"1","article-title":"Sexual risk behaviour in a cohort of HIV\u2010negative and HIV\u2010positive Rwandan women","volume":"147","author":"Mukanyangezi MF","year":"2018","journal-title":"Epidemiol Infect"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02227-07"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2013.84"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174117"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit181"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2017.00178"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djm010"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(99)00043-0"},{"key":"e_1_2_6_21_1","first-page":"689","article-title":"Assessment of risk factors and human papillomavirus (HPV) related pathogenetic mechanisms of CIN in HIV\u2010positive and HIV\u2010negative women. Study design and baseline data of the HPV\u2010PathogenISS study","volume":"25","author":"Branca M","year":"2004","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1086\/428779"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20188"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-96"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604972"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1086\/587698"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e328324061a"},{"key":"e_1_2_6_28_1","first-page":"3528","article-title":"Human papilloma virus infection and cervical cytomorphological changing among intrauterine contraception users","volume":"20","author":"Frega A","year":"2016","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29719"},{"key":"e_1_2_6_30_1","first-page":"357","article-title":"Chlamydial infection in female lower genital tract and its correlation with cervical smear abnormalities","volume":"113","author":"Peitsidis P","year":"2012","journal-title":"Bratisl Lek Listy"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-015-0819-1"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-016-2584-1"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61684-5"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600650"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.23.2995"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04268.x"},{"key":"e_1_2_6_37_1","first-page":"137","article-title":"Human papillomavirus related cervical cancer and anticipated vaccination challenges in Ethiopia","volume":"10","author":"Gebremariam T","year":"2016","journal-title":"Int J Health Sci (Qassim)"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603737"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-015-0015-z"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-015-1125-8"},{"key":"e_1_2_6_41_1","first-page":"12","article-title":"The risk of sexually transmitted infection and its influence on condom use among pregnant women in the Kintampo North Municipality of Ghana","volume":"2017","author":"Ali Abdulai M","year":"2017","journal-title":"J Sex Transm Dis"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760150393"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-308"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000272"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-018-0946-2"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-015-0286-2"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12041-018-0907-y"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhiv.12782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.12782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.12782","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.12782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T01:47:25Z","timestamp":1694137645000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.12782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,18]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/hiv.12782"],"URL":"https:\/\/doi.org\/10.1111\/hiv.12782","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"type":"print","value":"1464-2662"},{"type":"electronic","value":"1468-1293"}],"subject":[],"published":{"date-parts":[[2019,7,18]]},"assertion":[{"value":"2019-06-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}