{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:24:19Z","timestamp":1789809859529,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Organiza\u00e7\u00e3o Panamericana de Sa\u00fade"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the study was to describe the characteristics, impact and outreach of post\u2010exposure prophylaxis (PEP) for sexual exposure in Brazil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used secondary data from the Brazilian Ministry of Health to describe the impact of national guidelines on the frequency of prescription, user profile and antiretroviral regimens. We also estimated the number of potentially averted HIV infections attributable to PEP for consented sexual exposure between 2009 and 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 260\u00a0457 PEP regimens were prescribed to individuals\u00a0\u2265\u00a014\u00a0years old; 104\u00a0613 (40.2%) were prescribed for consented sexual exposure, with an increasing frequency since 2011. Drugs used in PEP regimens underwent significant modifications during the period, reflecting national recommendations. We estimated that there were up to 3138 potentially averted HIV infections attributable to PEP for consented sexual exposure between 2009 and 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the context of a combined HIV prevention strategy, PEP is still an essential tool for individuals for whom other methods are contraindicated or fail to be applied.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12825","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T13:44:25Z","timestamp":1573825465000},"page":"240-245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Post\u2010exposure prophylaxis following consented sexual exposure: impact of national recommendations on user profile, drug regimens and estimates of averted HIV infections"],"prefix":"10.1111","volume":"21","author":[{"given":"IO","family":"Pereira","sequence":"first","affiliation":[{"name":"Department of Chronic Conditions and Sexually Transmitted Infections Ministry of Health of Brazil Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ARP","family":"Pascom","sequence":"additional","affiliation":[{"name":"Department of Chronic Conditions and Sexually Transmitted Infections Ministry of Health of Brazil Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Mosimann","sequence":"additional","affiliation":[{"name":"Department of Chronic Conditions and Sexually Transmitted Infections Ministry of Health of Brazil Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Barros Perini","sequence":"additional","affiliation":[{"name":"Department of Chronic Conditions and Sexually Transmitted Infections Ministry of Health of Brazil Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RA","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Chronic Conditions and Sexually Transmitted Infections Ministry of Health of Brazil Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Rick","sequence":"additional","affiliation":[{"name":"Department of Chronic Conditions and Sexually Transmitted Infections Ministry of Health of Brazil Brasilia Brazil"},{"name":"Aids Health Care Foundation Global Programm Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Benzaken","sequence":"additional","affiliation":[{"name":"Aids Health Care Foundation Global Programm Sao Paulo Brazil"},{"name":"Tropical Medicine Foundation Heitor Vieira Dourado Manaus Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6660-3088","authenticated-orcid":false,"given":"VI","family":"Avelino\u2010Silva","sequence":"additional","affiliation":[{"name":"Department of Infectious and Parasitic Diseases University of Sao Paulo Medical School Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Updated guidelines for antiretroviral postexposure prophylaxis after sexual injection drug use or other nonoccupational exposure to HIV\u2014 United States 2016. Centers for Disease Control and Prevention U.S. Department of Health and Human Services. Available athttps:\/\/stacks.cdc.gov\/view\/cdc\/38856(accessed 19 October 2019)."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-7-78"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.5.4265-4273.1998"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.20.9771-9775.2000"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711203372101"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200404150-00010"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462416641813"},{"key":"e_1_2_6_9_1","unstructured":"Post\u2010exposure prophylaxis after non\u2010occupational and occupational exposure to HIV. Australian National Guidelines. Second edition 2016. Available athttps:\/\/www.ashm.org.au\/products\/product\/978-1-920773-47-2(accessed 19 October 2019)."},{"key":"e_1_2_6_10_1","unstructured":"Ministerio da Saude. Secretaria de Vigil\u00e2ncia em Saude. Departamento de Vigilancia Prevencao e Controle das Infeccoes Sexualmente Transmissiveis do HIV\/Aids e das Hepatites Virais.Clinical protocol and therapeutic guidelines for post\u2010exposure prophylaxis (PEP) for the risk of HIV STIs and viral hepatitis infections. Brasilia 2018.http:\/\/www.aids.gov.br\/pt-br\/pub\/2015\/protocolo-clinico-e-diretrizes-terapeuticas-para-profilaxia-pos-exposicao-pep-de-risco(accessed 19 October 2019)."},{"key":"e_1_2_6_11_1","unstructured":"Ministerio da Saude Secretaria de Vigilancia em Saude Departamento de DST Aids e Hepatites Virais.Recomenda\u00e7\u00f5es para terapia antirretroviral em adultos infectados pelo HIV\u2010 2008. Suplemento III \u2013 Tratamento e preven\u00e7\u00e3o. Brasilia 2010."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010573"},{"key":"e_1_2_6_13_1","unstructured":"Ministerio da Saude Secretaria de Vigilancia em Saude.Relatorio de Monitoramento Clinico do HIV. Brasilia 2017. Available athttp:\/\/www.aids.gov.br\/pt-br\/pub\/2018\/relatorio-de-monitoramento-clinico-do-hiv-2018(accessed 07 November 2019)."},{"key":"e_1_2_6_14_1","unstructured":"Ministerio da Saude Secretaria de Vigilancia em Saude. Boletim Epidemiologico HIV Aids 2017. Brasilia2017Available athttp:\/\/www.aids.gov.br\/pt-br\/pub\/2017\/boletim-epidemiologico-hivaids-2017(accessed 19 October 2019)."},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2005.014886"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200403260-00010"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200005260-00016"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2007.007216"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462414547525"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ094"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197998"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhiv.12825","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.12825","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.12825","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.12825","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T15:17:09Z","timestamp":1694013429000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.12825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,15]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/hiv.12825"],"URL":"https:\/\/doi.org\/10.1111\/hiv.12825","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,15]]},"assertion":[{"value":"2019-10-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}