{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:38:52Z","timestamp":1791920332833,"version":"4.3.4"},"reference-count":8,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The European AIDS Clinical Society (EACS) Guidelines cover key aspects of HIV management with major updates every two\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Guideline highlights<\/jats:title><jats:p>The 2019 Guidelines were extended with a new section focusing on drug\u2013drug interactions and other prescribing issues in people living with HIV (PLWH). The recommendations for treatment\u2010na\u00efve PLWH were updated with four preferred regimens favouring unboosted integrase inhibitors. A two\u2010drug regimen with dolutegravir and lamivudine, and a three\u2010drug regimen including doravirine were also added to the recommended initial regimens. Lower thresholds for hypertension were expanded to all PLWH and for cardiovascular disease prevention, the 10\u2010year predicted risk threshold for consideration of antiretroviral therapy (ART) modification was lowered from 20% to 10%. Frailty and obesity were added as new topics. It was specified to use urine albumin to creatinine ratio to screen for glomerular disease and urine protein to creatinine ratio for tubular diseases, and thresholds were streamlined with the Kidney Disease: Improving Global Outcomes (KDIGO) recommendations. Hepatitis C virus (HCV) treatment recommendations were split into preferred and alternative treatment options. The algorithm for management of recently acquired HCV infection was updated and includes recommendations for early chronic infection management. Treatment of resistant tuberculosis (TB) was streamlined with the World Health Organization (WHO) recommendations, and new tables on immune reconstitution inflammatory syndrome, on when to start ART in the presence of opportunistic infections and on TB drug dosing were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The EACS Guidelines underwent major revisions of all sections in 2019. They are available in four different formats including a new interactive web\u2010based version and are translated into Chinese, French, German, Japanese, Portuguese, Russian and Spanish.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12878","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:53:47Z","timestamp":1599180827000},"page":"617-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":135,"title":["2019 update of the European AIDS Clinical Society Guidelines for treatment of people living with HIV version 10.0"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6436-6461","authenticated-orcid":false,"given":"L","family":"Ryom","sequence":"first","affiliation":[{"name":"CHIP Center of Excellence for Health, Immunity and Infections, Department of Infectious Diseases Section 2100 Center for Cardiac, Vascular, Pulmonary and Infectious Diseases Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Cotter","sequence":"additional","affiliation":[{"name":"University College Dublin Centre for Experimental Pathogen Host Research Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"De Miguel","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit La Paz Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"B\u00e9guelin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Inselspital Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Podlekareva","sequence":"additional","affiliation":[{"name":"CHIP Center of Excellence for Health, Immunity and Infections, Department of Infectious Diseases Section 2100 Center for Cardiac, Vascular, Pulmonary and Infectious Diseases Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JR","family":"Arribas","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit La Paz Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Marzolini","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology Departments of Medicine and Clinical Research University Hospital of Basel and University of Basel Basel Switzerland"},{"name":"Department of Molecular and Clinical Pharmacology Institute of Translational Medicine University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PGM","family":"Mallon","sequence":"additional","affiliation":[{"name":"University College Dublin Centre for Experimental Pathogen Host Research Dublin 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5724-3914","authenticated-orcid":false,"given":"G","family":"Guaraldi","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical, Dental and Morphological Sciences University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5847-8416","authenticated-orcid":false,"given":"A","family":"Winston","sequence":"additional","affiliation":[{"name":"Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Bhagani","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases\/HIV Medicine Royal Free London NHS Trust Institute of Global Health University College London London 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