{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:33:35Z","timestamp":1789187615732,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010877","name":"ViiV Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>People with HIV (PWHIV) are likely to need therapies for comorbidities as they age. We assessed risk of drug\u2013drug interactions (DDIs) in PWHIV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Climate\u2010HIV electronic recording system was used to cross\u2010sectionally analyse records from PWHIV aged \u2265\u00a018\u00a0years attending four UK HIV units with a current antiretroviral (ARV) prescription in February 2018. Antiretroviral and non\u2010ARV medications were categorized by clinical significance of DDIs (University of Liverpool DDI tool). Potential DDIs were predicted using treatment guidelines for commonly recorded comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 4630 PWHIV (44% female), 41% were \u2265\u00a050\u00a0years old. The average number of non\u2010ARV comedications increased from &lt;\u00a01 for patients aged \u2264\u00a024\u00a0years to &gt;\u00a05 for patients aged \u2265\u00a075\u00a0years; 65% were taking one or more non\u2010ARV comedications. The median (interquartile range) number of non\u2010ARVs was 1 (0\u20132) and 2 (1\u20135) for those aged &lt;\u00a050 and \u2265\u00a050\u00a0years, respectively. Common comorbidities\/concurrent health conditions occurred more frequently in patients aged \u2265\u00a050\u00a0years <jats:italic>vs<\/jats:italic>. &lt;\u00a050 (53% <jats:italic>vs<\/jats:italic>. 34%). Boosted protease inhibitors were associated with the highest proportion of contraindicated comedications; dolutegravir and raltegravir had the fewest. For non\u2010ARVs, sildenafil and quetiapine were most likely to result in DDIs. Guideline\u2010recommended treatments for hepatitis C, hepatitis B, and tuberculosis had the highest proportions of contraindications when combined with ARV regimens, while treatments for hepatitis C, malignancy, and mental health conditions had the highest proportion of combinations potentially causing DDIs requiring dose monitoring or adjustment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Non\u2010ARV use by PWHIV is high and increases with age. Treatment decisions for ageing PWHIV should consider guideline recommendations for comorbidities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12879","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T06:33:43Z","timestamp":1594881223000},"page":"471-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Polypharmacy and potential drug\u2013drug interactions for people with HIV in the UK from the Climate\u2010HIV database"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9424-2873","authenticated-orcid":false,"given":"C","family":"Okoli","sequence":"first","affiliation":[{"name":"ViiV Healthcare Brentford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Schwenk","sequence":"additional","affiliation":[{"name":"North Middlesex University Hospital NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Radford","sequence":"additional","affiliation":[{"name":"ViiV Healthcare Brentford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Myland","sequence":"additional","affiliation":[{"name":"IQVIA Real World Insights, UK &amp; Ireland London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Taylor","sequence":"additional","affiliation":[{"name":"Birmingham Heartlands HIV Service Department of Infection and Immunology Birmingham Heartlands Hospital University Hospitals Birmingham NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Darley","sequence":"additional","affiliation":[{"name":"Nottingham University Hospitals NHS Trust Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Barnes","sequence":"additional","affiliation":[{"name":"Birmingham Heartlands HIV Service Department of Infection and Immunology Birmingham Heartlands Hospital University Hospitals Birmingham NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Fox","sequence":"additional","affiliation":[{"name":"Nottingham University Hospitals NHS Trust Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Grimson","sequence":"additional","affiliation":[{"name":"IQVIA Real World Insights, UK &amp; Ireland London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Reeves","sequence":"additional","affiliation":[{"name":"Homerton University Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Munshi","sequence":"additional","affiliation":[{"name":"Homerton University Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Croucher","sequence":"additional","affiliation":[{"name":"Homerton University Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Boxall","sequence":"additional","affiliation":[{"name":"IQVIA Real World Insights, UK &amp; Ireland London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Benn","sequence":"additional","affiliation":[{"name":"ViiV Healthcare Brentford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Paice","sequence":"additional","affiliation":[{"name":"ViiV Healthcare Brentford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"van Wyk","sequence":"additional","affiliation":[{"name":"ViiV Healthcare Brentford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Khoo","sequence":"additional","affiliation":[{"name":"University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61113-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-013-0093-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2010.00859.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.6.6.695"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr248"},{"key":"e_1_2_7_7_1","unstructured":"University of Liverpool HIV Drug Interactions. 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