{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:03:51Z","timestamp":1790748231854,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD16\/0025\/0017"],"award-info":[{"award-number":["RD16\/0025\/0017"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We assessed the prevalence of potentially inappropriate medication (PIM) among older (\u2265\u00a065\u00a0years) people living with HIV (O\u2010PLWH) in the region of Madrid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed the dispensation registry of community and hospital pharmacies from the Madrid Regional Health Service (SERMAS) for the period between 1 January and 30 June 2017, looking specifically at PIMs according to the 2019 Beers criteria. Co\u2010medications were classified according to the Anatomical Therapeutic Chemical (ATC) classification system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 6\u00a0636\u00a0451 individuals received medications. Of these individuals, 22\u00a0945 received antiretrovirals (ARVs), and of these 1292 were O\u2010PLWH. Overall, 1135 (87.8%) O\u2010PLWH were taking at least one co\u2010medication, and polypharmacy (at least five co\u2010medications) was observed in 852 individuals (65.9%). A PIM was identified in 482 (37.3%) O\u2010PLWH. Factors independently associated with PIM were polypharmacy [adjusted odds ratio (aOR) 7.08; 95% confidence interval (CI) 5.16\u20139.72] and female sex (aOR 1.75; 95% CI 1.30\u20132.35). The distribution of PIMs according to ATC drug class were nervous system drugs (<jats:italic>n<\/jats:italic>\u00a0=\u00a0369; 28.6%), musculoskeletal system drugs (<jats:italic>n<\/jats:italic>\u00a0=\u00a0140; 10.8%), gastrointestinal and metabolism drugs (<jats:italic>n<\/jats:italic>\u00a0=\u00a072; 5.6%), cardiovascular drugs (<jats:italic>n<\/jats:italic>\u00a0=\u00a061; 4.7%), respiratory system drugs (<jats:italic>n<\/jats:italic>\u00a0=\u00a013; 1.0%), antineoplastic and immunomodulating drugs (<jats:italic>n<\/jats:italic>\u00a0=\u00a010; 0.8%), and systemic anti\u2010infectives (<jats:italic>n<\/jats:italic>\u00a0=\u00a02; 0.2%). Five drugs accounted for 84.8% of the 482O PLWH with PIMs: lorazepam (38.2%), ibuprofen (18.0%), diazepam (10.2%), metoclopramide (9.9%), and zolpidem (8.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prescription of PIMs is highly prevalent in O\u2010PLWH. Consistent with data in uninfected elderly people, the most frequently observed PIMs were benzodiazepines and nonsteroidal anti\u2010inflammatory drugs . Targeted interventions are warranted to reduce inappropriate prescribing and polypharmacy in this vulnerable population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12883","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T23:41:17Z","timestamp":1591746077000},"page":"541-546","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Potentially inappropriate medications in older adults living with HIV"],"prefix":"10.1111","volume":"21","author":[{"given":"B","family":"L\u00f3pez\u2010Centeno","sequence":"first","affiliation":[{"name":"Directorate for Pharmacy and Health Products Madrid Regional Health Service (SERMAS) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Badenes\u2010Olmedo","sequence":"additional","affiliation":[{"name":"Ontology Engineering Group (OEG) School of Telecommunications and System Engineering Polytechnic University of Madrid (UPM) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Mataix\u2010Sanjuan","sequence":"additional","affiliation":[{"name":"Directorate for Pharmacy and Health Products Madrid Regional Health Service (SERMAS) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JM","family":"Bell\u00f3n","sequence":"additional","affiliation":[{"name":"Gregorio Mara\u00f1\u00f3n General Hospital Institute of Health Research Gregorio Mara\u00f1\u00f3n (IiSGM) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"P\u00e9rez\u2010Latorre","sequence":"additional","affiliation":[{"name":"Gregorio Mara\u00f1\u00f3n General Hospital Institute of Health Research Gregorio Mara\u00f1\u00f3n (IiSGM) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JC","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Gregorio Mara\u00f1\u00f3n General Hospital Institute of Health Research Gregorio Mara\u00f1\u00f3n (IiSGM) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Bened\u00ed","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Pharmacy Complutense Universtiy (UCM) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Khoo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Marzolini","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases &amp; Hospital Epidemiology University Hospital of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MJ","family":"Calvo\u2010Alc\u00e1ntara","sequence":"additional","affiliation":[{"name":"Directorate for Pharmacy and Health Products Madrid Regional Health Service (SERMAS) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8541-8200","authenticated-orcid":false,"given":"J","family":"Berenguer","sequence":"additional","affiliation":[{"name":"Gregorio Mara\u00f1\u00f3n General Hospital Institute of Health Research Gregorio Mara\u00f1\u00f3n (IiSGM) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-015-1860-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz811"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-018-2446-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15767"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.5414\/CPP46072"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-010-0041-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir627"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.215"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-012-0016-1"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105425"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-015-1950-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2016.11.025"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2019.1627200"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042098619880122"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12695"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2043"},{"key":"e_1_2_7_18_1","volume-title":"19th International Workshop on Clinical Pharmacology of Antiviral Therapy","author":"Livio F","year":"2018"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2196\/14130"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-002378"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2012.3972"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-019-02785-z"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhiv.12883","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.12883","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.12883","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.12883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T12:53:55Z","timestamp":1693918435000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.12883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,9]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/hiv.12883"],"URL":"https:\/\/doi.org\/10.1111\/hiv.12883","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,9]]},"assertion":[{"value":"2020-05-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}