{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:02Z","timestamp":1787014322896,"version":"build-2736575974"},"reference-count":7,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Rapid antiretroviral therapy (ART) initiation is recommended in early HIV infection (EHI), even in the absence of baseline viral resistance test result. We analysed time to viral suppression according to ART regimen started in a cohort of patients diagnosed with EHI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical records of individuals consecutively diagnosed with EHI between July 2016\u2010June 2018 were reviewed. The distribution of clinical, virological and immunological factors was compared in treatment groups using the Mann\u2013Whitney U\u2010test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>262 individuals (97% MSM) were diagnosed with EHI. 58% of patients agreed to start ART within 14 days of diagnosis. Tenofovir\u2010based combinations were prescribed to all patients. DRV\/b was the most commonly prescribed third agent (78%), when genotypic resistance testing was not available at time of ART choice. Switching to INSTI was encouraged once VRT became available and 27% switched from DRV\/b to INSTI (mainly RAL) within 28 days from ART start. Those receiving INSTI were more likely to have a baseline viral load exceeding 1 million HIV\u20101 RNA copies\/mL compared with those starting with DRV\/b. Rapid start with INSTI regimens resulted in quicker viral suppression than when DRV\/b was chosen in EHI, even when that was subsequently switched to INSTI. Retention in care following rapid ART start was achieved by all patients at 24 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Starting an INSTI\u2010based ART combination was associated with quicker viral suppression than when a protease inhibitor\u2010based combination was chosen. No differences in the achievement of viral suppression or in retention in care were observed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.12900","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T09:27:22Z","timestamp":1598952442000},"page":"613-615","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Rapid ART start in early HIV infection: Time to viral load suppression and retention in care in a London cohort"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2960-2748","authenticated-orcid":false,"given":"Nicol\u00f2","family":"Girometti","sequence":"first","affiliation":[{"name":"Chelsea &amp; Westminster Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Lander","sequence":"additional","affiliation":[{"name":"Chelsea &amp; Westminster Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"McOwan","sequence":"additional","affiliation":[{"name":"Chelsea &amp; Westminster Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nneka","family":"Nwokolo","sequence":"additional","affiliation":[{"name":"Chelsea &amp; Westminster Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Boffito","sequence":"additional","affiliation":[{"name":"Chelsea &amp; Westminster Hospital NHS Foundation Trust London UK"},{"name":"Imperial College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3070-1281","authenticated-orcid":false,"given":"Gary","family":"Whitlock","sequence":"additional","affiliation":[{"name":"Chelsea &amp; Westminster Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Dean Street Collaborative group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507198"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506816"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600693"},{"key":"e_1_2_3_5_1","unstructured":"Panel on Antiretroviral Guidelines for Adults and Adolescents.Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV. Department of Health and Human Services. Available athttp:\/\/www.aidsinfo.nih.gov\/ContentFiles\/AdultandAdolescentGL.pdf. (accessed 14 October 2019)."},{"key":"e_1_2_3_6_1","unstructured":"EACS guidelines. (2018) Available atwww.eacsociety.org\/guidelines\/eacs\u2010guidelines\/eacs\u2010guidelines.htmlwww.eacsociety.org\/files\/2018_guidelines\u20109.1\u2010english.pdf(PDF). (accessed 14 October 2019)."},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12780"},{"key":"e_1_2_3_8_1","unstructured":"TittleV BoffitoM GedelaKet al.Insufficient PrEP monitoring and HIV drug resistance. BASHH conference Birmingham UK.2019. Oral presentation (O16)."}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.12900","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.12900","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.12900","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T12:15:09Z","timestamp":1693138509000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.12900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":7,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/hiv.12900"],"URL":"https:\/\/doi.org\/10.1111\/hiv.12900","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"2019-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}