{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:12:51Z","timestamp":1747185171866,"version":"3.40.5"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>People living with HIV (PLWH) have increased risk of cardiovascular diseases compared with uninfected populations. We assessed structural cardiac abnormalities and their associated risk factors in well\u2010treated PLWH and uninfected controls using multidetector computed tomography (MDCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>People living with HIV and age\u2010 and sex\u2010matched uninfected controls underwent MDCT to determine left atrial volume (LAV), left ventricular diastolic volume (LVDV), right ventricular diastolic volume (RVDV) and left ventricular mass (LVM). All outcomes were indexed to body surface area (BSA) (LAVi, LVDVi, RVDVi and LVMi).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 592 PLWH and 1184 uninfected controls were included in the study. PLWH had smaller mean (SD) LAVi [40 (8) <jats:italic>vs<\/jats:italic>. 41 (9)\u00a0mL\/m<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002] and LVDVi [61 (13) <jats:italic>vs<\/jats:italic>. 65 (14)\u00a0mL\/m<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001] but larger RVDVi [89 (18) <jats:italic>vs<\/jats:italic>. 86 (17)\u00a0mL\/m<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001] than uninfected controls. HIV was independently associated with 7\u00a0mL (95% CI: \u221210 to \u22123) smaller LVDV, and with 12\u00a0mL (95% CI: 8\u201316) larger RVDV, and 4\u00a0g (95% CI: 1\u20136) larger LVM after adjustment for cardiovascular risk factors and BSA. Large RVDV in PLWH was not associated with obstructive lung function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HIV was independently associated with smaller LVDV and larger RVDV and LVM. Alterations in cardiac chamber volumes in PLWH were mainly minor. The clinical impact of these findings is uncertain, but it seems unlikely that alterations in cardiac chamber volumes explain the increased burden of cardiovascular disease previously observed in PLWH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12916","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T16:18:49Z","timestamp":1601050729000},"page":"625-634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cardiac chamber volumes and left ventricular mass in people living with HIV and matched uninfected controls"],"prefix":"10.1111","volume":"21","author":[{"given":"L","family":"Krebs\u2010Demmer","sequence":"first","affiliation":[{"name":"Viro\u2010immunology Research Unit Department of Infectious Diseases 8632 Rigshospitalet University of Copenhagen Copenhagen 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