{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T17:58:43Z","timestamp":1781027923711,"version":"3.54.1"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The characteristics of critically ill HIV\u2010positive patients and the causes of their admission to intensive care units (ICUs) are only known through retrospective and unicentric studies. This study aims to fill this knowledge gap.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a prospective, multicentre cohort study of short\u2010 and medium\u2010term prognostic factors. The setting consisted of ICUs of three tertiary referral hospitals from the three largest metropolitan areas in Brazil in the period January 2014 to November 2015. In all, 161 HIV patients over 18\u00a0years old were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The clinical data of the outcomes (ICU mortality, hospital mortality and 90\u2010day survival) were extracted from medical records using the REDCap<jats:sup>\u00ae\ufe0f<\/jats:sup> web\u2010based form and analysed with the MedCalc<jats:sup>\u00ae<\/jats:sup><jats:bold><jats:sup>\ufe0f<\/jats:sup><\/jats:bold> application. Median age was 41.7 [interquartile range (IQR): 34\u201350] years, the Simplified Acute Physiologic Score 3 (SAPS 3) was 64 (IQR: 56\u201374), and the Sequential Organ Failure Assessment Score (SOFA) was 6 (IQR: 4\u20139) points. The main causes of admission were sepsis (54.5%) and acute respiratory failure (13.7%). ICU and hospital mortality rates were 32.3% and 40.4%, respectively. In a multivariate analysis, time until ICU admission\u00a0\u2265\u00a03\u00a0days (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0013), performance status (Eastern Cooperative Oncology Group score, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0344), coma (Glasgow Coma Scale\u00a0\u2264\u00a08 points, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0213) and sepsis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0003) were associated with increased hospital mortality. Coma (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0002) and sepsis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0008) were independently associated with 90\u2010day survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Delayed ICU admission and the severity of critical illness determine the short\u2010 and medium\u2010term mortality rates of HIV\u2010infected patients admitted to the ICU, rather than factors associated with HIV infection. These results suggest that prognostic factors of HIV\u2010infected patients in the ICU are similar to those of non\u2010HIV\u2010infected populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12939","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T13:07:06Z","timestamp":1599052026000},"page":"650-658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Short\u2010 and medium\u2010term prognosis of HIV\u2010infected patients receiving intensive care: a Brazilian multicentre prospective cohort study"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6781-6125","authenticated-orcid":false,"given":"HB","family":"Andrade","sequence":"first","affiliation":[{"name":"Intensive Care Unit of the Evandro Chagas National Institute of Infectology Oswaldo Cruz Foundation (Fiocruz) Rio de Janeiro RJ Brazil"},{"name":"Sexually Transmitted Diseases Sector 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