{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:21:57Z","timestamp":1762543317657,"version":"3.40.5"},"reference-count":64,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["IR.SUMS.REC.1398.311"],"award-info":[{"award-number":["IR.SUMS.REC.1398.311"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Gender differences in the efficacy of treatment and the mortality of HIV\u2010infected patients have not yet been fully elucidated. For the first time, we used data from a 20\u2010year cohort of people living with HIV (PLWH) in four provinces (Fars, Bushehr, Bandar Abbas, and Kohgiluyeh and Boyer\u2010Ahmad) in the southern part of Iran to assess the gender difference in all\u2010cause mortality in PLWH in Iran.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed data for 1216 patients aged \u2265 15\u00a0years who were diagnosed with HIV\/AIDS between 1997 and 2017. Three hundred and fourteen (25.8%) were women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The death rate from all causes among women was 13.7% <jats:italic>vs<\/jats:italic>. 43.8% among men (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). All\u2010cause mortality was significantly associated with gender [the adjusted hazard ratio (aHR) for men compared with women was 3.20], not being on antiretroviral therapy (ART) compared with being on ART at the last visit (aHR\u00a05.42), older age (aHR\u00a01.03), delayed HIV diagnosis compared with early diagnosis (aHR\u00a01.72), history of incarceration (aHR\u00a01.57), higher log CD4 count at diagnosis (aHR\u00a00.54), and prophylaxis for <jats:italic>Pneumocystis<\/jats:italic> pneumonia (aHR\u00a00.09).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this 20\u2010year cohort study suggest that gender is an important predictor of survival among HIV\u2010infected patients. Improving early HIV diagnosis and early ART initiation in men, as well as increased access to hepatitis C virus treatment are needed to increase the survival rate of HIV\u2010infected patients in Iran.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.12940","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T12:35:51Z","timestamp":1599050151000},"page":"659-667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Gender difference in all\u2010cause mortality of people living with HIV in Iran: findings from a 20\u2010year cohort study"],"prefix":"10.1111","volume":"21","author":[{"given":"Z","family":"Gheibi","sequence":"first","affiliation":[{"name":"Department of Epidemiology Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0185-5807","authenticated-orcid":false,"given":"M","family":"Dianatinasab","sequence":"additional","affiliation":[{"name":"Center for Health Related Social and Behavioral Sciences Research Shahroud University of Medical Sciences Shahroud Iran"},{"name":"Department of Complex Genetics and Epidemiology School of Nutrition and Translational Research in Metabolism Maastricht University Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Haghparast","sequence":"additional","affiliation":[{"name":"School of Nursing and Midwifery Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Mirzazadeh","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California San Francisco San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9362-328X","authenticated-orcid":false,"given":"M","family":"Fararouei","sequence":"additional","affiliation":[{"name":"Shiraz HIV\/AIDS Research Center Institute of Health Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(17)30066-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(19)30196-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","unstructured":"Trends in HIV\/AIDS morbidity and mortality in Eastern Mediterranean countries 1990\u20132015: findings from the Global Burden of Disease 2015 study.International journal of public health.2018;63:123\u2013136.","DOI":"10.1007\/s00038-017-1023-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081355"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001304"},{"key":"e_1_2_8_7_1","unstructured":"Global AIDS update 2016.Joint United Nations Programme on HIV\/AIDS(https:\/\/www.unaids.org\/en\/resources\/documents\/2016\/Global\u2010AIDS\u2010update\u20102016). 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