{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:24:04Z","timestamp":1788326644930,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Non\u2010treponemal serological tests are used to monitor treatment response during syphilis infection. Syphilis\u2010 and HIV\u2010coinfected patients may experience incomplete resolution in non\u2010treponemal titres, which is referred to as the serofast state. The goal of this study was to evaluate risk factors for serofast state in HIV\u2010infected patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      From November 2015 to June 2018, 1530 HIV\u2010positive patients were tested for syphilis using a\n                      <jats:italic>Treponema pallidum<\/jats:italic>\n                      particle agglutination (TPPA) assay. Among TPPA\u2010positive patients, medical records were reviewed for early syphilis infection. Serofast state was defined as a less than four\u2010fold decrease in non\u2010treponemal antibody titres during a 6\u2010month follow\u2010up period in the absence of symptoms of syphilis. Baseline characteristics were tested as predictive factors of serological response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In all, 515 patients (33.7%) tested positive in TPPA assays, and in 163 patients at least one previous syphilis infection was documented. A total of 61 out of 163 patients (37.4%) were in a serofast state. A history of previous syphilis infection (61\n                      <jats:italic>vs<\/jats:italic>\n                      . 43%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.04) was more common in serofast patients than in patients with serological cure after 6\u00a0months. Non\u2010treponemal titres \u2265\u00a01:32 before therapy (47\n                      <jats:italic>vs<\/jats:italic>\n                      . 25%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.005) and adjunctive corticosteroids to prevent the Jarisch\u2013Herxheimer reaction (35% vs 15%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.006) were associated with serological cure after 6\u00a0months, but corticosteroid therapy had no influence at 12\u00a0months. The intensity of syphilis treatment did not affect serological cure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Corticosteroids for prevention of the Jarisch\u2013Herxheimer reaction were associated with earlier serological cure. Although serological response is the accredited surrogate method to monitor syphilis treatment, the biological significance of the serofast state remains unclear.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.12985","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T01:51:29Z","timestamp":1604109089000},"page":"165-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Predictors of serofast state after treatment for early syphilis in HIV\u2010infected patients"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1075-4362","authenticated-orcid":false,"given":"G","family":"Paul","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department I of Internal Medicine University of Cologne Cologne Germany"},{"name":"Department of Gastroenterology, Hepatology, Pneumology and Infectious Diseases Katharinenhospital Klinikum Stuttgart Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Wesselmann","sequence":"additional","affiliation":[{"name":"Department of Medicine I Bonn University Hospital Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Adzic","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department I of Internal Medicine University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2989-0436","authenticated-orcid":false,"given":"JJ","family":"Malin","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department I of Internal Medicine University of Cologne Cologne Germany"},{"name":"German Center for Infection Research (DZIF) Bonn\u2010Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Suarez","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department I of Internal Medicine University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Priesner","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department I of Internal Medicine University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"K\u00fcmmerle","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department I of Internal Medicine University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Wyen","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department I of Internal Medicine University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department I of Internal Medicine University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"van Bremen","sequence":"additional","affiliation":[{"name":"Department of Medicine I Bonn University Hospital Bonn Germany"},{"name":"German Center for Infection Research (DZIF) Bonn\u2010Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Schlabe","sequence":"additional","affiliation":[{"name":"Department of Medicine I Bonn University Hospital Bonn Germany"},{"name":"German Center for Infection Research (DZIF) Bonn\u2010Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u2010C","family":"Wasmuth","sequence":"additional","affiliation":[{"name":"Department of Medicine I Bonn University Hospital Bonn Germany"},{"name":"German Center for Infection Research (DZIF) Bonn\u2010Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Boesecke","sequence":"additional","affiliation":[{"name":"Department of Medicine I Bonn University Hospital Bonn Germany"},{"name":"German Center for Infection Research (DZIF) Bonn\u2010Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"F\u00e4tkenheuer","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department I of Internal Medicine University of Cologne Cologne Germany"},{"name":"German Center for Infection Research (DZIF) Bonn\u2010Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Rockstroh","sequence":"additional","affiliation":[{"name":"Department of Medicine I Bonn University Hospital Bonn Germany"},{"name":"German Center for Infection Research (DZIF) Bonn\u2010Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Schwarze\u2010Zander","sequence":"additional","affiliation":[{"name":"Department of Medicine I Bonn University Hospital Bonn Germany"},{"name":"German Center for Infection Research (DZIF) Bonn\u2010Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department I of Internal Medicine University of Cologne Cologne Germany"},{"name":"German Center for Infection Research (DZIF) Bonn\u2010Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"issue":"50","key":"e_1_2_7_2_1","first-page":"545","article-title":"Syphilis in Deutschland im Jahr 2018 \u2013 Anstieg der Vorjahre stagniert auf hohem Niveau","volume":"50","author":"Jansen K","year":"2019","journal-title":"Epid 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