{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:13:02Z","timestamp":1747185182076,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Micro\u2010elimination of hepatitis C virus (HCV) in people living with HIV (PLHIV) and co\u2010infected with HCV has been proposed as a key contribution to the overall goal of HCV elimination. While other studies have examined micro\u2010elimination in HIV\u2010treated cohorts, few have considered HCV micro\u2010elimination among those not treated for HIV or at a national level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Through data linkage of national and sentinel surveillance data, we examined the extent of HCV testing, diagnosis and treatment among a cohort of PLHIV in Scotland identified through the national database of HIV\u2010diagnosed individuals, up to the end of 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 5018 PLHIV, an estimated 797 (15%) had never been tested for HCV and 70 (9%) of these had undiagnosed chronic HCV. The odds of never having been tested for HCV were the highest in those not on HIV treatment [adjusted odds ratio (aOR)\u00a0=\u00a07.21, 95% confidence interval (CI): 5.15\u201310.10). Overall HCV antibody positivity was 11%, and it was at its highest among people who inject drugs (49%). Most of those with chronic HCV (91%) had attended an HCV treatment clinic but only half had been successfully treated (54% for those on HIV treatment, 12% for those not) by the end of 2017. The odds of never having been treated for HCV were the highest in those not on HIV treatment (aOR\u00a0=\u00a03.60, 95% CI: 1.59\u20138.15).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data demonstrate that micro\u2010elimination of HCV in PLHIV is achievable but progress will require increased effort to engage and treat those co\u2010infected, including those not being treated for their HIV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13032","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T06:43:44Z","timestamp":1608273824000},"page":"334-345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Increased case\u2010finding and uptake of direct\u2010acting antiviral treatment essential for micro\u2010elimination of hepatitis C among people living with HIV: a national record linkage study"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6536-5949","authenticated-orcid":false,"given":"A","family":"McLeod","sequence":"first","affiliation":[{"name":"Health Protection Scotland Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SJ","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"Health Protection Scotland Glasgow UK"},{"name":"School of Health and Life Sciences Glasgow Caledonian University Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Smith","sequence":"additional","affiliation":[{"name":"Health Protection Scotland Glasgow UK"},{"name":"School of Health and Life Sciences Glasgow Caledonian University Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Leen","sequence":"additional","affiliation":[{"name":"Regional Infectious Disease Unit Western General Hospital Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Clifford","sequence":"additional","affiliation":[{"name":"Regional Infectious Disease Unit Western General Hospital Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"McAuley","sequence":"additional","affiliation":[{"name":"Health Protection Scotland Glasgow UK"},{"name":"School of Health and Life Sciences Glasgow Caledonian University Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LA","family":"Wallace","sequence":"additional","affiliation":[{"name":"Health Protection Scotland Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ST","family":"Barclay","sequence":"additional","affiliation":[{"name":"Glasgow Royal Infirmary Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Bramley","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences Glasgow Caledonian University Glasgow UK"},{"name":"Stirling Royal Infirmary Stirling UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JF","family":"Dillon","sequence":"additional","affiliation":[{"name":"Ninewells Hospital and Medical School Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Fraser","sequence":"additional","affiliation":[{"name":"Queen Elizabeth University Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RN","family":"Gunson","sequence":"additional","affiliation":[{"name":"West of Scotland Specialist Virology Centre Glasgow Royal Infirmary Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PC","family":"Hayes","sequence":"additional","affiliation":[{"name":"Royal Infirmary Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Kennedy","sequence":"additional","affiliation":[{"name":"University Hospital Monklands Lanarkshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Peters","sequence":"additional","affiliation":[{"name":"The Brownlee Centre Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Templeton","sequence":"additional","affiliation":[{"name":"East of Scotland Specialist Virology Centre Royal Infirmary of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DJ","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Health Protection Scotland Glasgow UK"},{"name":"School of Health and Life Sciences Glasgow Caledonian University Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.20.1.22146"},{"key":"e_1_2_8_4_1","unstructured":"WHO Global health sector strategy on viral hepatitis 2016\u20132021. 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