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Exclusion criteria were viral hepatitis co\u2010infection (<jats:italic>n<\/jats:italic>\u00a0=\u00a090), abusive alcohol intake (<jats:italic>n<\/jats:italic>\u00a0=\u00a061), missing data (<jats:italic>n<\/jats:italic>\u00a0=\u00a047) or unreliable TE (<jats:italic>n<\/jats:italic>\u00a0=\u00a039). NAFLD was defined by controlled attenuation parameter\u00a0\u2265\u00a0248\u00a0dB\/m and advanced fibrosis by liver stiffness measurement\u00a0\u2265\u00a08.7\u00a0kPa with M probe or \u2265\u00a07.2\u00a0kPa with XL probe. Biomarkers for NAFLD [Steato\u2010ELSA, Fatty Liver Index (FLI), Hepatic Steatosis Index (HSI), NAFLD\u2010Liver Fat Score (NAFLD\u2010LFS)] and fibrosis [Fibrosis\u20104 score (FIB\u20104), Aspartate\u2010to\u2010Platelet Ratio Index (APRI) and NAFLD Fibrosis Score (NFS)] were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 437 patients [57% female, age\u00a0=\u00a044 (interquartile range: 35\u201352)\u00a0years, body mass index (BMI)\u00a0=\u00a026.1 (23.4\u201329.3)\u00a0kg\/m<jats:sup>2<\/jats:sup>, CD4\u00a0=\u00a0660 (427\u2013901)\u00a0cells\/\u03bcL] were included. The prevalence [95% confidence interval (CI)] of NAFLD and advanced fibrosis were 38.2% (33.8\u201342.9) and 10.5% (8.0\u201313.8), respectively. The areas (95% CI) under the receiver operator curve (AUROCs) for diagnosis of NAFLD were 0.854 (0.818\u20130.889), 0.840 (0.804\u20130.877), 0.805 (0.762\u20130.847) and 0.793 (0.750\u20130.836) for Steato\u2010ELSA, FLI, HSI and NAFLD\u2010LFS (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), respectively. All tests yielded satisfactory sensitivities, specificities and negative predictive values (NPVs). The AUROCs (95% CI) for diagnosis of advanced fibrosis were 0.736 (0.659\u20130.814), 0.700 (0.614\u20130.7851) and 0.795 (0.726\u20130.864) for FIB\u20104, APRI and NFS (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.077), respectively. These tests yielded high specificities and negative predictive values (NPVs)\u00a0&gt;\u00a090%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Biomarkers for NAFLD had a good accuracy and those for fibrosis had high specificities and NPVs. These tests should be integrated to HIV care to detect NAFLD and to exclude advanced liver fibrosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13060","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T04:24:28Z","timestamp":1612585468000},"page":"445-456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Diagnostic value of serological biomarkers for detection of non\u2010alcoholic fatty liver disease (NAFLD) and\/or advanced liver fibrosis in people living with HIV"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0944-855X","authenticated-orcid":false,"given":"C","family":"Yanavich","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Research in STD\/AIDS (LAPCLIN\u2010AIDS) National Institute of Infectious Diseases Evandro Chagas (INI) Oswaldo Cruz Foundation (FIOCRUZ) Rio de Janeiro Brazil"},{"name":"Department of Pediatrics 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