{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:13:03Z","timestamp":1747185183259,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100003896","name":"Henry M. 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However, the clinical, virological and neurocognitive effects of syphilis during acute HIV\u20101 (AHI) remain unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pre\u2010antiretroviral therapy laboratory outcomes and neurocognitive performance in a four\u2010test battery in the SEARCH10\/RV254 AHI cohort were compared according to syphilis status, determined by serum <jats:italic>Treponema pallidum<\/jats:italic> haemagglutination (TPHA), Venereal Disease Research Laboratory (VDRL) and syphilis treatment history. Impaired cognitive performance was defined as having <jats:italic>z<\/jats:italic>\u2010scores \u2264\u00a0\u22121 in at least two tests or \u2264\u00a0\u22122 in at least one test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 595 AHI participants (97% male, median age of 26\u00a0years and estimated duration of HIV\u20101 infection of 19\u00a0days), 119 (20%) had history of syphilis (TPHA\u2010positive), of whom 51 (9%) had untreated syphilis (TPHA\u2010positive\/VDRL\u2010positive\/without prior treatment). Compared with those without syphilis (TPHA\u2010negative), individuals with untreated syphilis had higher CD8 T\u2010lymphocyte levels but not higher plasma HIV\u20101 RNA or lower CD4 T\u2010lymphocyte levels. Taking into account estimated duration of HIV\u20101 infection (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and later Fiebig stages (III\u2013V) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), those with untreated syphilis had higher CD8 T\u2010lymphocyte levels (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.049). Individuals with any syphilis (TPHA\u2010positive), but not untreated syphilis, had higher odds of impaired cognitive performance than those without (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>During AHI, individuals with any history of syphilis (TPHA\u2010positive) had poorer cognitive performance than those without syphilis. However, syphilis was not associated with worsened HIV disease measures as described in chronic infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13079","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T07:06:50Z","timestamp":1615964810000},"page":"502-511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and laboratory impact of concomitant syphilis infection during acute HIV"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4071-4409","authenticated-orcid":false,"given":"P","family":"Chan","sequence":"first","affiliation":[{"name":"SEARCH Thai Red Cross AIDS Research Centre Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DJ","family":"Colby","sequence":"additional","affiliation":[{"name":"SEARCH Thai Red Cross AIDS Research Centre Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Kroon","sequence":"additional","affiliation":[{"name":"SEARCH Thai Red Cross AIDS Research Centre Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Sacdalan","sequence":"additional","affiliation":[{"name":"SEARCH Thai Red Cross AIDS Research Centre Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Pinyakorn","sequence":"additional","affiliation":[{"name":"The Henry M. Jackson Foundation for the Advancement of Military Medicine Bethesda MD USA"},{"name":"U.S. Military HIV Research Program Walter Reed Army Institute of Research Silver Spring MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Paul","sequence":"additional","affiliation":[{"name":"Missouri Institute of Mental Health University of Missouri\u2010St Louis St Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Robb","sequence":"additional","affiliation":[{"name":"The Henry M. 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