{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T07:36:17Z","timestamp":1769844977062,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> is a worldwide infection, but little is known about the efficacy of treatment for <jats:italic>H<\/jats:italic>.\u00a0<jats:italic>pylori<\/jats:italic> infection in HIV\u2010positive patients. The goal of this work was to evaluate outcomes after first\u2010line <jats:italic>H<\/jats:italic>.\u00a0<jats:italic>pylori<\/jats:italic> treatment and identify risk factors for failure in HIV\u2010positive patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This registry study of unmatched <jats:italic>H<\/jats:italic>.\u00a0<jats:italic>pylori<\/jats:italic>\u2010infected HIV\u2010positive patients and HIV\u2010negative obese pre\u2010bariatric surgery controls was performed in a tertiary university hospital. Cases were enrolled from 2006 to 2017, controls from 2007 to 2014, and both received standard of care. An additional \u2018optimal\u2019 subgroup of cases was enrolled prospectively from 2017 to 2019 which was treated only on the basis of antibiogram, drug interaction search and additional support by one referent physician. <jats:italic>Helicobacter<\/jats:italic>\u00a0<jats:italic>pylori<\/jats:italic> eradication failure rates were compared according to clinical, microbiological and pathological parameters and treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analysed 258 HIV\u2010positive patients and 204 HIV\u2010negative control patients. <jats:italic>Helicobacter<\/jats:italic>\u00a0<jats:italic>pylori<\/jats:italic> eradication failure rates were markedly greater in cases (24.1%) than in controls (8.8%). The proportions of levofloxacin and metronidazole resistance were greater in cases than in controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Among cases treated with <jats:italic>H<\/jats:italic>.\u00a0<jats:italic>pylori<\/jats:italic> triple therapy (S3T), the \u2018optimal\u2019 subgroup experienced a 9.5% failure rate <jats:italic>vs<\/jats:italic>. 28.6% with other strategies (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). Risk factors for failure were <jats:italic>H<\/jats:italic>.\u00a0<jats:italic>pylori<\/jats:italic> treatment strategy, exposure to antiretroviral treatment, and alcohol status. Overall, positive HIV status was a risk factor for S3T eradication failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients co\u2010infected with <jats:italic>H. pylori<\/jats:italic> and HIV frequently failed to eradicate <jats:italic>H<\/jats:italic>.\u00a0<jats:italic>pylori<\/jats:italic> and this was related to treatment strategy, antiretroviral exposure and lifestyle.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13083","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T19:20:18Z","timestamp":1616700018000},"page":"547-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Failure to eradicate <i>Helicobacter pylori<\/i> infection is more frequent among HIV\u2010positive patients"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7708-050X","authenticated-orcid":false,"given":"M","family":"Nkuize","sequence":"first","affiliation":[{"name":"Department of Gastroenterology University Hospital Saint Pierre Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Vanderpas","sequence":"additional","affiliation":[{"name":"Department of Hospital Hygiene University Hospital Saint Pierre Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Buset","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University Hospital Saint Pierre Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Delforge","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases University Hospital Saint Pierre Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u2010B","family":"Cadi\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery University Hospital Saint Pierre Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"De Wit","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases University Hospital Saint Pierre Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302084"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1710945"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312288"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01276.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.07.008"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.84a.14110"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/31.1.128"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2015.1073261"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2001.113959"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00518.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058217"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2009.00807.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12131"},{"key":"e_1_2_8_15_1","first-page":"226","article-title":"Prevalence of Helicobacter pylori and endoscopic findings in HIV seropositive patients with upper gastrointestinal tract symptoms at Kenyatta National Hospital, Nairobi","volume":"79","author":"Ali Mohamed FA","year":"2002","journal-title":"East Afr Med J"},{"key":"e_1_2_8_16_1","first-page":"641","article-title":"Proposal for use of a standard side effect scoring system in studies exploring Helicobacter pylori treatment regimens","volume":"8","author":"Boer WA","year":"1996","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"e_1_2_8_17_1","unstructured":"Clinical and Laboratory Standards Institute.Performance standards for antimicrobial susceptibility testing: 19th informational supplement. 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