{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T05:25:45Z","timestamp":1793510745738,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:00:00Z","timestamp":1617580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","award":["GILEAD SCIENCES. GLD14_00229"],"award-info":[{"award-number":["GILEAD SCIENCES. GLD14_00229"]}],"id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the prevalence of carotid atherosclerosis in virologically suppressed HIV patients with that of a community sample, and to evaluate the capacity of various cardiovascular risk (CVR) equations for predicting carotid atherosclerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional study with two randomly selected groups: HIV patients from an HIV unit and a control group drawn from the community. Participants were matched by age (30\u201380\u00a0years) and sex without history of cardiovascular disease. Carotid plaque, common carotid intima\u2013media thickness (cc\u2010IMT) and subclinical atherosclerosis (carotid plaque and\/or cc\u2010IMT\u00a0&gt;\u00a075<jats:sup>th<\/jats:sup> percentile) were assessed by carotid ultrasound. The Systematic Coronary Risk Evaluation (SCORE), Framingham, REGICOR, reduced Data Collection on Adverse Effects of Anti\u2010HIV Drugs (D:A:D), and COMVIH equations were applied, and their abilities to predict carotid plaque were compared using the area under the curve (AUC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Each group included 379 subjects (77.8% men, age 49.7\u00a0years). Duration of antiretroviral therapy was 15.5\u00a0years. There were no differences between the groups for carotid plaque (HIV, 33.2%; control, 31.3%), mean cc\u2010IMT (HIV, 0.63\u00a0mm; control, 0.61\u00a0mm) or subclinical atherosclerosis (HIV, 42.9%; control, 47.9%). Thymidine analogues were independently associated with subclinical atherosclerosis in HIV\u2010infected patients. CVR equations revealed AUCs between 0.715 and 0.807 for prediction of carotid plaque; prediction was better in the control group and did not improve when HIV\u2010adapted scales were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The features of carotid atherosclerosis did not differ between the HIV\u2010infected and the control group, although CVR equations were more predictive for carotid plaque in controls than in HIV\u2010infected patients. HIV\u2010specific equations did not improve prediction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13093","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T08:44:20Z","timestamp":1617612260000},"page":"581-591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Carotid atherosclerosis in virologically suppressed HIV patients: comparison with a healthy sample and prediction by cardiovascular risk equations"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0047-1991","authenticated-orcid":false,"given":"M","family":"Saumoy","sequence":"first","affiliation":[{"name":"HIV and STD Unit Infectious Disease Department Bellvitge University Hospital Hospitalet de Llobregat Spain"},{"name":"Bellvitge Institute for Biomedical Research Hospitalet de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Di Yacovo","sequence":"additional","affiliation":[{"name":"HIV and STD Unit Infectious Disease Department Bellvitge University Hospital Hospitalet de Llobregat Spain"},{"name":"Bellvitge Institute for Biomedical Research Hospitalet de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Hospital del Mar Institute for Medical Research (IMIM) Barcelona Spain"},{"name":"Consortium for Biomedical Research in Cardiovascular Diseases (CIBERCV) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JL","family":"S\u00e1nchez\u2010Quesada","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute IIB Sant Pau Barcelona Spain"},{"name":"Biochemistry and Molecular Biology Department Universitat Aut\u00f2noma Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JM","family":"Valdivielso","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute of Lleida IRB Vascular and Renal Translational Research Group UDETMA Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Subirana","sequence":"additional","affiliation":[{"name":"Hospital del Mar Institute for Medical Research (IMIM) Barcelona Spain"},{"name":"Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Imaz","sequence":"additional","affiliation":[{"name":"HIV and STD Unit Infectious Disease Department Bellvitge University Hospital Hospitalet de Llobregat Spain"},{"name":"Bellvitge Institute for Biomedical Research Hospitalet de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0073-873X","authenticated-orcid":false,"given":"JM","family":"Tiraboschi","sequence":"additional","affiliation":[{"name":"HIV and STD Unit Infectious Disease Department Bellvitge University Hospital Hospitalet de Llobregat Spain"},{"name":"Bellvitge Institute for Biomedical Research Hospitalet de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"HIV and STD Unit Infectious Disease Department Bellvitge University Hospital Hospitalet de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Ordo\u00f1ez\u2010LLanos","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute IIB Sant Pau Barcelona Spain"},{"name":"Biochemistry and Molecular Biology Department Universitat Aut\u00f2noma Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ben\u00edtez","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology Department Universitat Aut\u00f2noma Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Podzamczer","sequence":"additional","affiliation":[{"name":"HIV and STD Unit Infectious Disease Department Bellvitge University Hospital Hospitalet de Llobregat Spain"},{"name":"Bellvitge Institute for Biomedical Research Hospitalet de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Grau","sequence":"additional","affiliation":[{"name":"Hospital del Mar Institute for Medical Research (IMIM) Barcelona Spain"},{"name":"Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP) Barcelona Spain"},{"name":"Department of Medicine University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(17)30066-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.033369"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.036211"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir627"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028975"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw615"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw346"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJR.0b013e328336a150"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487312452964"},{"key":"e_1_2_6_11_1","unstructured":"EstradaV PalaciosR SerranoSet al.A calibration of the Framingham coronary risk function adapted to the characteristics of Spanish HIV\u2010infected patients [PE151\/2.] 15th European AIDS Conference 21\u201324 October 2015."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.05.007"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.177774"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12428"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328300581d"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw261"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jex239"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz455"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000002286"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2009.00766.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1161\/CIRCULATIONAHA.107.699579","article-title":"General cardiovascular risk profile for use in primary care: the Framingham heart study","volume":"117","author":"D\u2019Agostino RB","year":"2008","journal-title":"Circulation"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.57.8.634"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00114-3"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487315579291"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2012.04.026"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7141.2008.00021.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2013.05.030"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ325"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.111.000422"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.116.005995"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1586\/erc.10.28"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw683"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ586"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874192401105010049"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12300"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2006.0165"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12731"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1340-7"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.014310"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13093","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.13093","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T09:59:37Z","timestamp":1693303177000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.13093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,5]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/hiv.13093"],"URL":"https:\/\/doi.org\/10.1111\/hiv.13093","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,5]]},"assertion":[{"value":"2020-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}